Lin et al. show that MCM8 protects vascular health by mediating nitric-oxide-dependent mitophagy. The common East-Asian MCM8-P276 variant is ineffective in mitophagy, which potentiates cGAS-STING and type I interferon signaling in a mouse model of Kawasaki disease.
- Meng Lin
- Huifang Xian
- Yuxia Zhang
