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Showing 1–8 of 8 results
Advanced filters: Author: Yvan Fischer Clear advanced filters

  • Severe SARS-CoV-2 infection and COVID-19 can associate with autoantibodies neutralizing inflammatory cytokines. The authors here investigate the presence of autoantibodies targeting specific anti-inflammatory mediators. They identify severe COVID-19 to associate with autoantibodies depleting IL-1Ra and PGRN, which coincide with hyperphosphorylated antigen isoforms induced by inflammatory stress.

    • Lorenz Thurner
    • Natalie Fadle
    • Christoph Kessel
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • The interplay between hypoxic and acidic conditions in the tumor microenvironment is unclear. Here, the authors show that hypoxic and acidic tumor cells do not fully overlap and display a symbiotic interaction, relying on unsaturated fatty acids, which can be therapeutically targeted by inhibiting stearoylCoA desaturase 1 (SCD1).

    • Katarzyna Głowacka
    • Sébastien Ibanez
    • Olivier Feron
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Adipose tissue is composed of a number of adipocytes and a number of other cells including immune cells. Here the authors use single-cell sequencing of murine brown adipose tissue immune cells and describe multiple macrophage and monocyte subsets and show that monocytes contribute to brown adipose tissue expansion.

    • Alexandre Gallerand
    • Marion I. Stunault
    • Stoyan Ivanov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

    • Bethany L. Clark
    • Ana P. B. Carneiro
    • Maria P. Dias
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • This report identifies a new contribution of members of the miR-200 family to tumorigenesis. miR-200a and miR-141 specifically regulate p38α, contributing to the cellular modulation of oxidative stress responses. In this role, the miRs can accelerate ovarian tumorigenesis but also endow cancer cells with increased sensitivity to ROS-inducing chemotherapy. This two-part effect is reflected on the distinct association of the miRs with patient survival and may be informative for treatment decisions.

    • Bogdan Mateescu
    • Luciana Batista
    • Fatima Mechta-Grigoriou
    Research
    Nature Medicine
    Volume: 17, P: 1627-1635

  • Downstream of trajectory inference for cell lineages based on scRNA-seq data, differential expression analysis yields insight into biological processes. Here, Van den Berge et al. develop tradeSeq, a framework for the inference of within and between-lineage differential expression, based on negative binomial generalized additive models.

    • Koen Van den Berge
    • Hector Roux de Bézieux
    • Lieven Clement
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13