ADARs deaminate adenosines to inosines in double-stranded RNA (dsRNA). Interestingly, effects seen when ADARs are knocked out can be suppressed by additional knockout of RNAi machinery, suggesting competition between the two pathways. Genome-wide identification of ADAR targets shows that ADAR edits heavily in regions that generate siRNAs when ADAR is absent, indicating a role for ADAR in regulating dsRNA accumulation and thus siRNA production.
- Diane Wu
- Ayelet T Lamm
- Andrew Z Fire
