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Showing 1–4 of 4 results
Advanced filters: Author: Zahraa Rahal Clear advanced filters

  • Analyses of single epithelial cells from early-stage lung adenocarcinoma and normal lung identifies a population of intermediate cells that may have an increased likelihood of transforming to tumour cells after injury such as tobacco exposure.

    • Guangchun Han
    • Ansam Sinjab
    • Humam Kadara
    ResearchOpen Access
    Nature
    Volume: 627, P: 656-663

  • Despite advances in drug development, some patients with non-small-cell lung cancer (NSCLC) have suboptimal responses to treatment. The authors of this Review provide an overview of the complexity of the tumour microenvironment in NSCLC, including the influence of patient-related factors, such as ageing, sex and health disparities, on the cancer–TME crosstalk, and discuss how various therapeutic strategies interact with and are influenced by the TME in NSCLC.

    • Zahraa Rahal
    • Roy El Darzi
    • Humam Kadara
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 463-482

  • While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively intercept progression. In this Review, Mazzilli et al. explore recent advances in identifying premalignant lesions, highlighting their disease aetiology and devising approaches for stratification and interventions aimed at halting the progression to cancer.

    • Sarah A. Mazzilli
    • Zahraa Rahal
    • Avrum E. Spira
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 379-392