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Showing 1–7 of 7 results

Advanced filters: Author: Zee-Yong Park Clear advanced filters

Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane

Si Hoon Park
Juhyun Han
Hyun Kyu Song
Amendments and CorrectionsOpen Access28 Oct 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1810
Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development

The regulation of KRAS oncoprotein stability remains to be completely determined. Here the authors identify that USP9X-mediated deubiquitination of KRAS protein is dependent on scaffolding protein NDRG3, suggesting KRAS-NDRG3 interaction as a targetable vulnerability in KRAS-driven cancers.

Han Koo
Kyung Chan Park
Dong Chul Lee
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-17
A sexually transmitted sugar orchestrates reproductive responses to nutritional stress

Seminal fluid is high in sugars, primarily to aid in sperm motility though it is unclear whether they serve other roles. Here they use Drosophila to identify a bioactive sugar, venerose, that stimulates female brain neurons to boost germline stem cell proliferation and sperm storage.

Seong-Jin Kim
Kang-Min Lee
Young-Joon Kim
ResearchOpen Access01 Oct 2024
Nature Communications

Volume: 15, P: 1-17
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation

The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation.

Ji Hae Seo
Ji-Hyeon Park
Kyu-Won Kim
ResearchOpen Access06 Oct 2016
Nature Communications

Volume: 7, P: 1-14
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane

The authors present the full-length dimeric TRIM72 E3 ubiquitin ligase and the architecture of its high-order assembly bound to a phosphatidylserine-enriched membrane, providing insights into its role in membrane repair and ubiquitylation.

Si Hoon Park
Juhyun Han
Hyun Kyu Song
ResearchOpen Access28 Sept 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1695-1706
The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis

In experimentally induced osteoarthritis, chondrocytes show increased uptake and metabolism of cholesterol, implicating the CH25H–CYP7B1–RORα axis in the pathogenesis of osteoarthritis.

Wan-Su Choi
Gyuseok Lee
Jang-Soo Chun
Research06 Feb 2019
Nature

Volume: 566, P: 254-258
A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser

Si Hoon Park
Jaehyun Park
Hyun Kyu Song
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-10