Nature Search

Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis

Nociceptive sensory nerves infiltrate the peripheral trauma area, mediating the biased repair response due to the formation of fibrotic mesenchymal stromal cells (MSCs) neurogenic niche. Nociceptive sensory neuron-derived nerve growth factor activates the TrkA receptors in MSCs and triggers the Hif1α-Twist1 pathway, driving the differentiation of MSCs into myofibroblasts to mediate fibrosis. TPX-0005 exerts therapeutic effects by inhibiting TrkA to reverse fibrosis.

Yanhao Li
Sa Pang
Shen Liu
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-20
ETV7 limits the antiviral and antitumor efficacy of CD8⁺ T cells by diverting their fate toward exhaustion

Jiang and colleagues identify ETV7 as a transcriptional node that skews CD8⁺ T cell transcriptional profiles toward exhaustion, consequently limiting antiviral and antitumor efficacy, and show that it can be targeted in CAR T cells to enhance efficacy.

Jie Cheng
Yifeng Xiao
Peng Jiang
Research13 Jan 2025
Nature Cancer

Volume: 6, P: 338-356
A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein

In this study, the authors report a potent neutralizing antibody targeting a conserved epitope within RSV pre-F that shows higher antiviral activity against both RSV-A and -B subgroups in vitro and in small animal models than FDA-approved prophylactic agents.

Yongpeng Sun
Liqin Liu
Ningshao Xia
ResearchOpen Access21 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Genomic landscape of liver cancer

A new exome sequencing study of individuals with hepatocellular carcinoma (HCC) reveals imprints of mutagenic exposure and identifies new genes contributing to tumorigenesis. This work joins several recent publications reporting whole-genome, exome and RNA sequencing in HCC, which together provide a comprehensive genomic landscape and new insights into the etiology of liver cancer.

Zemin Zhang
News & Views26 Sept 2012
Nature Genetics

Volume: 44, P: 1075-1077
Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

MYC oncogene promotes tumourigenesis by coordinating cancer cell proliferation with metabolic adaptation to the consequent excessive oxidative stress. Here, the authors show that nudix hydrolase 1 (NUDT1) is a MYC-driven metabolic vulnerability and generate a NUDT1 protein degrader to treat preclinical MYC-associated cancer.

Minhui Ye
Yingzhe Fang
Guoliang Qing
ResearchOpen Access16 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Aging-related intervertebral disc degeneration (IVDD) is a leading cause of lower back pain. Here, the authors perform scRNA-seq analysis of intervertebral disc cells from patients, and identify cell populations and mechanisms associated with IVDD.

Fan Chen
Linchuan Lei
Jianru Wang
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

The genetic basis of gastric cancer, the fourth most common cancer worldwide, remains poorly understood. Here, the authors sequence and analyse the exomes and transcriptomes of primary gastric tumours and cell lines, and identify a ZAK kinase isoform that may have an oncogenic role in gastric cancer.

Jinfeng Liu
Mark McCleland
Zemin Zhang
ResearchOpen Access08 May 2014
Nature Communications

Volume: 5, P: 1-8
The mutation spectrum revealed by paired genome sequences from a lung cancer patient

Complete genome sequencing has already provided insights into the mutation spectra of several cancer types. Here, the first complete sequences are provided of a primary lung tumour and adjacent normal tissue. Comparison of the two reveals a variety of somatic mutations in the cancer genome, including changes in the KRAS proto-oncogene. The results reveal a distinct pattern of selection against mutations within expressed genes compared to non-expressed genes, and selection against mutations in promoter regions.

William Lee
Zhaoshi Jiang
Zemin Zhang
Research27 May 2010
Nature

Volume: 465, P: 473-477
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.

Yang Liu
Shuai He
Jin-Xin Bei
ResearchOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1-18
Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy

Hypoxia can promote tumor escape from immune surveillance and immunotherapy. Here, the authors show that hypoxia induces T and NK cell dysfunction through HIF1α-mediated epigenetic suppression of effector gene expression, conferring resistance to anti-PD1 blockade in triple negative breast cancer models.

Shijun Ma
Yue Zhao
Qiang Yu
ResearchOpen Access15 Jul 2022
Nature Communications

Volume: 13, P: 1-18
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

Olivier Delaneau
Jonathan Marchini
Leena Peltonenz
Research13 Jun 2014
Nature Communications

Volume: 5, P: 1-9
An integrated map of genetic variation from 1,092 human genomes

This report from the 1000 Genomes Project describes the genomes of 1,092 individuals from 14 human populations, providing a resource for common and low-frequency variant analysis in individuals from diverse populations; hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites, can be found in each individual.

Gil A. McVean
David M. Altshuler (Co-Chair)
Gil A. McVean
ResearchOpen Access31 Oct 2012
Nature

Volume: 491, P: 56-65
Regulatory effect of carbon pricing on the negative impacts of coal phase-out

Zemin Wu
Qiuwei Wu
Zhiling Hui
ResearchOpen Access31 Mar 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-13
A comprehensive transcriptional portrait of human cancer cell lines

A comprehensive analysis of RNA sequencing and single-nucleotide polymorphism (SNP) array data provides new insights into the biology of 675 human cancer cell lines

Christiaan Klijn
Steffen Durinck
Zemin Zhang
Research08 Dec 2014
Nature Biotechnology

Volume: 33, P: 306-312
Author Correction: π-HuB: the proteomic navigator of the human body

Fuchu He
Ruedi Aebersold
Zemin Zhang
Amendments and Corrections23 Dec 2024
Nature

Volume: 637, P: E22
A global reference for human genetic variation

Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

Adam Auton
Gonçalo R. Abecasis
Gonçalo R. Abecasis
ResearchOpen Access30 Sept 2015
Nature

Volume: 526, P: 68-74
Haplotype-phased genome assemblies and annotation of the northern white-cheeked gibbon (Nomascus leucogenys)

Zhonglai Luo
Libo Jiang
Fengtang Yang
ResearchOpen Access25 Nov 2024
Scientific Data

Volume: 11, P: 1-8
High Expression of long non-coding RNA PVT1 predicts metastasis in Han and Uygur Patients with Gastric Cancer in Xinjiang, China

Xianxian Ren
Dongdong Cao
Zemin Pan
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla)

Bin Han and colleagues report the draft genome of moso bamboo, an important non-timber forest product. RNA sequencing analysis of bamboo flowering tissues suggests a connection between drought-responsive genes and potential flowering genes.

Zhenhua Peng
Ying Lu
Zehui Jiang
ResearchOpen Access24 Feb 2013
Nature Genetics

Volume: 45, P: 456-461
A comparative analysis of toxicity and treatment outcomes of adaptive radiotherapy and intensity-modulated radiotherapy in cervical cancer

Xiaohan Liu
Wei Tian
Zemin Xiao
ResearchOpen Access10 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

Shunlun Chen
Linchuan Lei
Jianru Wang
ResearchOpen Access19 Apr 2022
Experimental & Molecular Medicine

Volume: 54, P: 518-530
π-HuB: the proteomic navigator of the human body

We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our understanding of human biology.

Fuchu He
Ruedi Aebersold
Zemin Zhang
Reviews11 Dec 2024
Nature

Volume: 636, P: 322-331
Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

Fan Chen
Guowei Jiang
Zhaomin Zheng
ResearchOpen Access18 Feb 2020
Bone Research

Volume: 8, P: 1-13
Association between Insomnia and Metabolic Syndrome in a Chinese Han Population: A Cross-sectional Study

Yan Wang
Tian Jiang
Junzheng Chen
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

Jingwen Ai
Jingxin Guo
Wenhong Zhang
ResearchOpen Access21 Oct 2022
Cell Discovery

Volume: 8, P: 1-15
Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration

Hua Wang
Peiheng He
Zhaomin Zheng
ResearchOpen Access13 Apr 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-14
International network of cancer genome projects

Thomas J. Hudson (Chairperson)
Warwick Anderson
Huanming Yang
Reviews15 Apr 2010
Nature

Volume: 464, P: 993-998

Search

Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis

ETV7 limits the antiviral and antitumor efficacy of CD8⁺ T cells by diverting their fate toward exhaustion

A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein

Genomic landscape of liver cancer

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

An integrated map of genetic variation from 1,092 human genomes

Regulatory effect of carbon pricing on the negative impacts of coal phase-out

A comprehensive transcriptional portrait of human cancer cell lines

Author Correction: π-HuB: the proteomic navigator of the human body

A global reference for human genetic variation

Haplotype-phased genome assemblies and annotation of the northern white-cheeked gibbon (Nomascus leucogenys)

High Expression of long non-coding RNA PVT1 predicts metastasis in Han and Uygur Patients with Gastric Cancer in Xinjiang, China

The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla)

A comparative analysis of toxicity and treatment outcomes of adaptive radiotherapy and intensity-modulated radiotherapy in cervical cancer

Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

π-HuB: the proteomic navigator of the human body

Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

Association between Insomnia and Metabolic Syndrome in a Chinese Han Population: A Cross-sectional Study

Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration

International network of cancer genome projects

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