IL-37 protein is downregulated in endometrial carcinoma cells compared to control endometrium. A mature form of IL-37b (IL-37bΔ1-45) effectively suppresses the migration and invasion of endometrial cancer cells by decreasing the expression of matrix metalloproteinase 2 (MMP2) via the Rac1/NF-κB signal pathway. This results in attenuated tumor metastasis in a peritoneal metastatic xenograft model of endometrial cancer.
- Xishuang Wang
- Zengtao Wei
- Xiaoyan Wang
