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Bone Research (4)
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Showing 1–21 of 21 results

Advanced filters: Author: Zengwu Shao Clear advanced filters

Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling

Synovitis is a key early driver of osteoarthritis (OA), and RANKL contributes to cartilage degradation in OA. Here the authors show that denosumab, an anti-RNKL antibody, reduces synovitis and delays OA progression in animal models and patients.

Yuxiang Hu
Wei Chen
Wei Tong
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Hsa_circ_0000285 functions as a competitive endogenous RNA to promote osteosarcoma progression by sponging hsa-miRNA-599

Zhicai Zhang
Feifei Pu
Zengwu Shao
Research29 Nov 2019
Gene Therapy

Volume: 27, P: 186-195
Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma

Regeneration of corneal stroma has been a challenge due to its sophisticated structure and the easy transformation of the keratocyte. Here, the authors use a hydrogel reinforced with orthogonally aligned fibres and serum free medium to maintain keratocyte phenotype for the in vivo stromal regeneration.

Bin Kong
Yun Chen
Shengli Mi
ResearchOpen Access18 Mar 2020
Nature Communications

Volume: 11, P: 1-12
Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

Osteoarthritis (OA) leads to joint degeneration, including the progressive loss of articular cartilage. Here the authors show that kindlin-2 expression is decreased in degenerate cartilage and that its overexpression decelerates the progression of OA in mice.

Xiaohao Wu
Yumei Lai
Guozhi Xiao
Research10 Feb 2022
Nature Aging

Volume: 2, P: 332-347
KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1

Li Cao
Ke Jia
Wei Wu
ResearchOpen Access12 Apr 2025
Oncogene

Volume: 44, P: 2186-2200
Correction to: IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells

Xinghuo Wu
Yu Song
Cao Yang
Amendments and CorrectionsOpen Access25 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-4
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway

Shuo Tian
Xuanzuo Chen
Yizhong Peng
ResearchOpen Access05 Feb 2024
Experimental & Molecular Medicine

Volume: 56, P: 408-421
Characterizing the tumor microenvironment at the single-cell level reveals a novel immune evasion mechanism in osteosarcoma

Weijian Liu
Hongzhi Hu
Yingze Zhang
ResearchOpen Access03 Jan 2023
Bone Research

Volume: 11, P: 1-12
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head

Wenkai Shao
Bo Wang
Yong Feng
ResearchOpen Access08 Nov 2024
Bone Research

Volume: 12, P: 1-22
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing

Weijian Liu
Wei Chen
Yingze Zhang
ResearchOpen Access05 Jul 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-17
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44

Baichuan Wang
Hongzhi Hu
Qiang Wu
ResearchOpen Access16 Apr 2024
Cell Death Discovery

Volume: 10, P: 1-10
Tissue-engineered cornea constructed with compressed collagen and laser-perforated electrospun mat

Bin Kong
Wei Sun
Shengli Mi
ResearchOpen Access20 Apr 2017
Scientific Reports

Volume: 7, P: 1-13
TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation

Mi Li
Wei Wu
Xin Jin
ResearchOpen Access04 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-13
Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

Sheng Chen
Xiaohao Wu
Guozhi Xiao
ResearchOpen Access10 Jan 2022
Bone Research

Volume: 10, P: 1-13
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3

Binwu Hu
Peng Wang
Zengwu Shao
ResearchOpen Access25 Mar 2022
Experimental & Molecular Medicine

Volume: 54, P: 309-323
An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP⁺ mononuclear cells and PDGF-BB secretion

Gehua Zhen
Yang Dan
Xu Cao
ResearchOpen Access01 Nov 2021
Bone Research

Volume: 9, P: 1-11
SGLT2 inhibitor activates the STING/IRF3/IFN-β pathway and induces immune infiltration in osteosarcoma

Wei Wu
Zhenhao Zhang
Zhicai Zhang
ResearchOpen Access03 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-13
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma

Binlong Zhong
Deyao Shi
Zengwu Shao
ResearchOpen Access18 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-16
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

Xuekun Fu
Bo Zhou
Guozhi Xiao
ResearchOpen Access26 Dec 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-13
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration

Xinghuo Wu
Wei Liu
Cao Yang
ResearchOpen Access27 Jul 2016
Scientific Reports

Volume: 6, P: 1-13
IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells

Xinghuo Wu
Yu Song
Cao Yang
ResearchOpen Access30 Jan 2017
Cell Death Discovery

Volume: 3, P: 1-12