This study elucidates the underlying cell death mechanism of NECSO (Necrosis by sodium overload). TRPM4-mediated sodium influx activates mitochondrial sodium–calcium exchange, which impairs mitochondrial energy production. This energy deficit inactivates the Na/K-ATPase, ultimately leading to cellular swelling and lysis.
- Yuhui Qiao
- Jianghuang Wang
- Qing Zhong