E3 ubiquitin ligase HRD1, a core component of the ER-associated degradation (ERAD) pathway, is essential for the TLR3-mediated innate immune response. HRD1 catalyzes polyubiquitination of TLR3 at lysine 813, which promotes its trafficking to endolysosomes and enables its proteolytic cleavage and functional activation.
- Lianfeng Zhao
- Zinan He
- Tingbo Liang
