Nature Search

Efficacy and safety of low-dose interleukin 2 for Behçet’s syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial

Behçet’s syndrome is a chronic inflammatory disease with oral ulcers being the most common symptom. Here authors present results from a phase 2 randomized double-blind placebo-controlled clinical trial that shows that systemic low dose interleukin-2 could be safely administered to these patients, and the therapy may improve their quality of life.

Tian Liu
Wenyan Zhou
Zhanguo Li
ResearchOpen Access07 Jan 2026
Nature Communications

P: 1-8
How COVID-19 is changing rheumatology clinical practice

The COVID-19 pandemic led to unprecedented changes in rheumatology clinical practice. In this Viewpoint article, we asked five experts to describe their experiences of the COVID-19 pandemic, how their clinical practice has changed, and the opportunities and challenges that lie ahead.

Eloisa Bonfá
Laure Gossec
Soumya Raychaudhuri
Reviews02 Nov 2020
Nature Reviews Rheumatology

Volume: 17, P: 11-15
Elevated Levels of Serum IgA Against Saccharomyces Cerevisiae Mannan in Patients with Rheumatoid Arthritis

Hui Dai
Zhanguo Li
Xiao-Ming Gao
Research01 Oct 2009
Cellular & Molecular Immunology

Volume: 6, P: 361-366
MDA5 regulates BCR signaling and B-cell function via NF-κB-mediated DNM1

Li Luo
Yi Wang
Chaohong Liu
Research01 Jan 2026
Cellular & Molecular Immunology

Volume: 23, P: 168-185
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.

Fanlei Hu
Xiang Jiang
Zhanguo Li
ResearchOpen Access20 Apr 2020
Nature Communications

Volume: 11, P: 1-14
Low-dose interleukin-2 treatment selectively modulates CD4⁺ T cell subsets in patients with systemic lupus erythematosus

Low-dose IL-2 treatment alters the abundance of regulatory T cells, IL-17-producing T cells and follicular helper T cells, but not of T helper type 1 and 2 cells, in patients with SLE.

Jing He
Xia Zhang
Zhanguo Li
Research08 Aug 2016
Nature Medicine

Volume: 22, P: 991-993
Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an lncRNA lnc-Smad3 on the promoter accessibility of the mouseSmad3locus.

Meng Xia
Juan Liu
Xuetao Cao
ResearchOpen Access09 Jun 2017
Nature Communications

Volume: 8, P: 1-13
Machine-learning-assisted and real-time-feedback-controlled growth of InAs/GaAs quantum dots

Finding the process parameters in molecular beam epitaxy for a specific density of quantum dots is a multidimensional optimization challenge. Here, the authors demonstrate real-time feedback controlled self-assembled InAs/GaAs QDs growth based on machine learning (ML) outputs.

Chao Shen
Wenkang Zhan
Zhanguo Wang
ResearchOpen Access29 Mar 2024
Nature Communications

Volume: 15, P: 1-11
MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation

B cell activation and differentiation entails metabolic remodelling, involving differential utilisation of monocarboxylates such as L-lactate and pyruvate. Here authors show by B-cell-specific genomic deletion of monocarboxylate transporter 1 (MCT1) that the consequential scarcity of pyruvate results in decreased acetylation of Histone H3 at K27, leading to decreased AID transcription and deficient class switching to IgG.

Wenna Chi
Na Kang
Ligong Chen
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-16
The metabolic hormone leptin promotes the function of T_FH cells and supports vaccine responses

T follicular helper (TFH) cell numbers are increased after vaccination and fewer of these cells might result in reduced vaccine responses. Here the authors show in mice and humans that leptin promotes T_FH differentiation and that low leptin levels can impair T_FH response to vaccines and virus protection in mice.

Jun Deng
Qian Chen
Di Yu
ResearchOpen Access24 May 2021
Nature Communications

Volume: 12, P: 1-15
Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study

Jiayang Jin
Jing Li
Zhanguo Li
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
The rise of IL-2 therapy — a picture beyond T_reg cells

Zhanguo Li
Jing He
Di Yu
Correspondence11 May 2017
Nature Reviews Rheumatology

Volume: 13, P: 386
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease

Telomere shortening in adipocyte progenitors, promoted by genetic Tert inactivation, is shown to compromise adipose tissue health and systemic metabolism, providing a possible mechanistic link between obesity, ageing and metabolic disease.

Zhanguo Gao
Alexes C. Daquinag
Mikhail G. Kolonin
Research14 Dec 2020
Nature Metabolism

Volume: 2, P: 1482-1497
Anisotropically biaxial strain in non-polar (112–0) plane In_xGa_1−xN/GaN layers investigated by X-ray reciprocal space mapping

Guijuan Zhao
Huijie Li
Zhanguo Wang
ResearchOpen Access03 Jul 2017
Scientific Reports

Volume: 7, P: 1-7
Anisotropic structural and optical properties of semi-polar (11–22) GaN grown on m-plane sapphire using double AlN buffer layers

Guijuan Zhao
Lianshan Wang
Zhanguo Wang
ResearchOpen Access10 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue

During the expansion of adipose tissue adipocyte progenitor cells proliferate and undergo adipogenesis. Here, the authors show that adipocyte progenitor cell proliferation in visceral adipose tissue has a diurnal pattern, which is dependent on both energy intake and the circadian clock.

Aleix Ribas-Latre
Rafael Bravo Santos
Kristin L. Eckel-Mahan
ResearchOpen Access09 Jun 2021
Nature Communications

Volume: 12, P: 1-18
A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study

Jing Li
Jun Xu
Jing He
ResearchOpen Access07 Feb 2025
Scientific Data

Volume: 12, P: 1-7
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

Betty Tsao, Jian Zhao, Nan Shen and colleagues show that a common missense variant in NCF1 confers susceptibility to multiple autoimmune diseases. This variant, which leads to reduced production of reactive oxygen species, accounts for the strong association signal previously identified in the GTF2IRD1–GTF2I region at 7q11.23.

Jian Zhao
Jianyang Ma
Betty P Tsao
Research30 Jan 2017
Nature Genetics

Volume: 49, P: 433-437
Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE

Haotian Zhou
Xiaozhen Zhao
Xiaolin Sun
ResearchOpen Access03 Apr 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-3
Analysing the phenotype development of soybean plants using low-cost 3D reconstruction

Rongsheng Zhu
Kai Sun
Qingshan Chen
ResearchOpen Access27 Apr 2020
Scientific Reports

Volume: 10, P: 1-17
Mechanical behavior analysis of fully grouted bolt under axial load

Xiujun Liu
Zhanguo Ma
ResearchOpen Access09 Jan 2023
Scientific Reports

Volume: 13, P: 1-23
Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial

Xiaoying Zhang
Miao Miao
Zhanguo Li
ResearchOpen Access07 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-8
Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression

Peng Li Zhou
Zhengyang Wu
Xinwei Han
ResearchOpen Access05 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-12
Targeting T_FH cells in human diseases and vaccination: rationale and practice

Yu et al. review the roles played by follicular helper T cells in sustaining germinal center B cell responses and vaccination strategies, as well as potential pathogenic autoimmune responses.

Di Yu
Lucy S. K. Walker
Zhanguo Li
Reviews11 Jul 2022
Nature Immunology

Volume: 23, P: 1157-1168
Characteristics of IgG4-related disease complicated with allergic rhinitis or chronic rhinosinusitis: a large cross-sectional cohort study

Qianyu Shi
Xiaoran Ning
Zhanguo Li
ResearchOpen Access14 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Novel missense mutations in MYO7A underlying postlingual high- or low-frequency non-syndromic hearing impairment in two large families from China

Yi Sun
Jing Chen
Huijun Yuan
Research09 Dec 2010
Journal of Human Genetics

Volume: 56, P: 64-70
Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance

Jianping Guo
Yanyan Gao
Zhanguo Li
ResearchOpen Access23 May 2018
Scientific Reports

Volume: 8, P: 1-8
Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift

Jian Sun
Yuan Jia
Zhanguo Li
Research07 Mar 2011
Cellular & Molecular Immunology

Volume: 8, P: 348-358

Search

Efficacy and safety of low-dose interleukin 2 for Behçet’s syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial

How COVID-19 is changing rheumatology clinical practice

Elevated Levels of Serum IgA Against Saccharomyces Cerevisiae Mannan in Patients with Rheumatoid Arthritis

MDA5 regulates BCR signaling and B-cell function via NF-κB-mediated DNM1

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Low-dose interleukin-2 treatment selectively modulates CD4⁺ T cell subsets in patients with systemic lupus erythematosus

Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

Machine-learning-assisted and real-time-feedback-controlled growth of InAs/GaAs quantum dots

MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation

The metabolic hormone leptin promotes the function of T_FH cells and supports vaccine responses

Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study

The rise of IL-2 therapy — a picture beyond T_reg cells

Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease

Anisotropically biaxial strain in non-polar (112–0) plane In_xGa_1−xN/GaN layers investigated by X-ray reciprocal space mapping

Anisotropic structural and optical properties of semi-polar (11–22) GaN grown on m-plane sapphire using double AlN buffer layers

Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue

A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE

Analysing the phenotype development of soybean plants using low-cost 3D reconstruction

Mechanical behavior analysis of fully grouted bolt under axial load

Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial

Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression

Targeting T_FH cells in human diseases and vaccination: rationale and practice

Characteristics of IgG4-related disease complicated with allergic rhinitis or chronic rhinosinusitis: a large cross-sectional cohort study

Novel missense mutations in MYO7A underlying postlingual high- or low-frequency non-syndromic hearing impairment in two large families from China

Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance

Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift

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