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Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure

Heart failure can be caused by cardiac fibroblasts replacing myocytes. Here, the authors use functional genomic data from fibroblasts, genetic signals enriched in people with heart disease, and gene perturbation analyses to link disease-associated regulatory elements to protein-coding genes.

Richard Gill
Daniel R. Lu
Yi-Hsiang Hsu
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Bireociclib plus fulvestrant for HR+/HER2- advanced female breast cancer progressed on or after endocrine therapy: phase 3 BRIGHT-2 study interim analysis

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

Jiayu Wang
Qingyuan Zhang
Binghe Xu
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-9
Author Correction: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

Jun Chen
Na Xu
Rongwen Xi
Amendments and Corrections19 Apr 2018
Nature Cell Biology

Volume: 20, P: 991
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Fang Qiu
Ruqi Tang
Xiong Ma
ResearchOpen Access20 Apr 2017
Nature Communications

Volume: 8, P: 1-8
Landscape of somatic alterations in large-scale solid tumors from an Asian population

Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.

Liqun Wu
Herui Yao
Minghui Wang
ResearchOpen Access23 Jul 2022
Nature Communications

Volume: 13, P: 1-11
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Recruitment of 53BP1 to double-strand DNA breaks is an important step in the cellular response to DNA damage. Here, the histone methyltransferase MMSET is shown to be responsible for localized increases in a histone modification that is involved in recruiting 53BP1. The mechanism of MMSET recruitment to DNA damage sites is also investigated.

Huadong Pei
Lindsey Zhang
Zhenkun Lou
Research02 Feb 2011
Nature

Volume: 470, P: 124-128
Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

Chen et al. demonstrate that transient Scute activation induces asymmetric division in Drosophila intestinal stem cells, which generates enteroendocrine progenitor cells that divide once before differentiation to yield a pair of enteroendocrine cells.

Jun Chen
Na Xu
Rongwen Xi
Research15 Jan 2018
Nature Cell Biology

Volume: 20, P: 152-161
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression

Xiaowen Zhang
Te Liu
Jinlan Jiang
ResearchOpen Access14 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Side-chain Engineering of Benzo[1,2-b:4,5-b’]dithiophene Core-structured Small Molecules for High-Performance Organic Solar Cells

Xinxing Yin
Qiaoshi An
Weihua Tang
ResearchOpen Access03 May 2016
Scientific Reports

Volume: 6, P: 1-10
Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing

Jing Xu
Zhongshan Li
Qiming Dai
ResearchOpen Access17 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway

Yan Zhang
Yi Ba
Chen-Yu Zhang
Research20 Mar 2007
Cell Research

Volume: 17, P: 363-373
Therapeutic potential of an anti-HER2 single chain antibody–DM1 conjugates for the treatment of HER2-positive cancer

Hang Zhang
Yuxi Wang
Jinliang Yang
ResearchOpen Access19 May 2017
Signal Transduction and Targeted Therapy

Volume: 2, P: 1-11

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