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Showing 1–4 of 4 results
Advanced filters: Author: Zhuanglin Shen Clear advanced filters

  • Functional evolution expands the catalytic repertoire of biosynthetic enzymes. Here, the authors reveal that a tripartite enzyme complex has evolved to catalyze Friedel–Crafts acylation through neofunctionalization of a conserved thiolase architecture.

    • Ge Liao
    • Ruolan Sun
    • Xiaoyu Tang
    ResearchOpen Access
    Nature Communications
    P: 1-14

  • The clinical efficacy of the antidiabetic drug acarbose is hampered by degradation by acarbose-preferred glucosidase (Apg) from the intestinal bacterium K. grimontii. Here the authors decipher the mechanism of Apg-mediated acarbose degradation and provide avenues towards the design of next-generation diabetes drugs.

    • Jiayong Huang
    • Zhuanglin Shen
    • Yang Gu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Complex many-body systems may contain numerous metastable states, making it very challenging to identify the ground state. Here, a computational method based on genetic tunneling is presented and demonstrated to identify efficiently the ground state in two-dimensional magnetic topological spin systems.

    • Qichen Xu
    • Zhuanglin Shen
    • Anna Delin
    ResearchOpen Access
    Communications Physics
    Volume: 6, P: 1-11