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Advanced filters: Author: Zi-Li Wan Clear advanced filters

Computational design of a high-precision mitochondrial DNA cytosine base editor

Mi et al. use de novo protein design to address bystander and off-target editing in base editing, resulting in a highly precise mitochondrial cytosine base editor that is valuable for studying and treating mitochondrial diseases.

Li Mi
Yu-Xuan Li
Peilong Lu
Research17 Nov 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2575-2586
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues

This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.

Qi-Xuan Cheng
Gang Xie
Yangming Wang
ResearchOpen Access11 Aug 2025
Nature Methods

Volume: 22, P: 1824-1835
Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway

Jin-qiang Zhang
Xiao-hui Wu
Zi-li You
Research18 Jul 2016
Acta Pharmacologica Sinica

Volume: 37, P: 1141-1153