Diversity oriented clicking (DOC) is an approach for creating a diverse range of molecules from click chemistry-reactive connective hubs. This Primer by Wang et al. covers the concepts behind DOC, the hubs and click chemistries available for DOC strategies, and the application of DOC-generated structures with a focus on the generation of molecular probes and bioactive molecules for drug discovery.
- Zifei Wang
- Joshua A. Homer
- John E. Moses
