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Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

Che Yu Lee
Ahyeon Hwang
Matthew J. Girgenti
ResearchOpen Access19 Jan 2026
Nature Communications

P: 1-17
Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Melinda Soeung
Xinmiao Yan
Pavlos Msaouel
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-23
A magnetic multi-layer soft robot for on-demand targeted adhesion

Magnetic soft robots offer a non-invasive way to deliver bioadhesives to targeted lesion sites to accelerate the healing. Authors present a magnetic multi-layer soft robot that is capable of performing navigated locomotion on biological tissues and on-demand multi-target adhesion at different sites.

Ziheng Chen
Yibin Wang
Jiangfan Yu
ResearchOpen Access20 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

Ahyeon Hwang
Mario Skarica
Matthew J. Girgenti
ResearchOpen Access18 Jun 2025
Nature

Volume: 643, P: 744-754
BRD4 inhibition sensitizes glioblastoma to radiotherapy by suppressing super-enhancer-driven COL1A1

Xichen Fan
Yi Yang
Jiajia Chen
Research14 Oct 2025
Oncogene

Volume: 44, P: 4462-4474
Minimum heart rate and mortality after cardiac surgery: retrospective analysis of the Multi-parameter Intelligent Monitoring in Intensive Care (MIMIC-III) database

Chaodi Luo
Zhenzhen Duan
Dan Han
ResearchOpen Access14 Feb 2023
Scientific Reports

Volume: 13, P: 1-9

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Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder

Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

A magnetic multi-layer soft robot for on-demand targeted adhesion

Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

BRD4 inhibition sensitizes glioblastoma to radiotherapy by suppressing super-enhancer-driven COL1A1

Minimum heart rate and mortality after cardiac surgery: retrospective analysis of the Multi-parameter Intelligent Monitoring in Intensive Care (MIMIC-III) database

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