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Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1

TLR7 has been shown to promote inflammatory autoimmunity. Here the authors investigate whether changes in RNA structure affect TLR signaling and show that a TLR7 binding lncRNA Lnc-Atg16l1 promotes development of autoimmunity in the mouse SLE model through enhancement of TLR7-MyD88 interactions.

Zongheng Yang
Shuchen Ji
Xuetao Cao
ResearchOpen Access25 Nov 2024
Nature Communications

Volume: 15, P: 1-13
Preservation versus resection of Denonvilliers’ fascia in total mesorectal excision for male rectal cancer: follow-up analysis of the randomized PUF-01 trial

Total mesorectal excision (TME) for rectal cancer can require partial resection of Denonvilliers’ fascia (DVF). Here the authors report the secondary outcomes of a randomized trial to evaluate the safety and effect of DVF preservation during laparoscopic TME on postoperative urogenital function and oncological safety in male patients with mid-low rectal cancer.

Jiafeng Fang
Bo Wei
Hongbo Wei
ResearchOpen Access20 Oct 2023
Nature Communications

Volume: 14, P: 1-9
Insights from indoor testing and numerical simulations of the Lanniqing Landslide in Zhaotong, Yunnan Province, China

Xu Zongheng
Chen Yunying
ResearchOpen Access31 Oct 2025
Scientific Reports

Volume: 15, P: 1-15
Creation of a eukaryotic multiplexed site-specific inversion system and its application for metabolic engineering

The site-specific DNA inversion system is a versatile tool for genetic engineering. Here, authors developed a multiplexed DNA inversion system, Rci51-5/multi-sfxa101, in eukaryotes, facilitating promoter substitution for metabolic engineering applications.

Jieyi Li
Simiao Gong
Ying-Jin Yuan
ResearchOpen Access24 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Single-cell spatiotemporal analysis of the lungs reveals Slamf9⁺ macrophages involved in viral clearance and inflammation resolution

Boyi Cong
Xuan Dong
Xuetao Cao
ResearchOpen Access16 Oct 2024
Cell Discovery

Volume: 10, P: 1-13
Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection

Boyi Cong
Xuan Dong
Xuetao Cao
ResearchOpen Access16 Oct 2024
Cell Discovery

Volume: 10, P: 1-12
Short-term outcome of intracorporeal ileocolonic anastomosis in patients with visceral obesity

Fangliang Guo
Cong Xia
Shuangyi Ren
ResearchOpen Access10 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Using ISU-GAN for unsupervised small sample defect detection

Yijing Guo
Linwei Zhong
Choujun Zhan
ResearchOpen Access08 Jul 2022
Scientific Reports

Volume: 12, P: 1-13

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Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1

Preservation versus resection of Denonvilliers’ fascia in total mesorectal excision for male rectal cancer: follow-up analysis of the randomized PUF-01 trial

Insights from indoor testing and numerical simulations of the Lanniqing Landslide in Zhaotong, Yunnan Province, China

Creation of a eukaryotic multiplexed site-specific inversion system and its application for metabolic engineering

Single-cell spatiotemporal analysis of the lungs reveals Slamf9⁺ macrophages involved in viral clearance and inflammation resolution

Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection

Short-term outcome of intracorporeal ileocolonic anastomosis in patients with visceral obesity

Using ISU-GAN for unsupervised small sample defect detection

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