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Bone marrow transplantation is the transference of bone marrow from one human or animal to another for a variety of purposes. Bone marrow transplantation can be used to treat certain blood disorders such as leukemia or immunodeficiency, but can also have serious complications such as graft-versus-host disease.
Here, the authors suggest that, when major histocompatibility complex class I is downregulated on allogenic or tumor cells, they are more susceptible to CD4+ T cell-mediated ferroptosis.
Tissue resident donor CD4 T cells contribute to chronic graft-versus-host disease (GVHD). To date, how these cells are maintained and the mechanism of pathogenesis remain undefined. Here, the authors perform transcriptomics and epigenomic analyses, they analyze memory CD4 T cell heterogeneity and differentiation pathways in tissues of mice with chronic GVHD and propose the selective targeting of stem-like memory T cell stemness or differentiation as a strategy to alleviate chronic tissue inflammation
Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.
