Erythropoiesis articles from across Nature Portfolio

This Review from Shokrollah Elahi considers how erythroid cells — including erythroid progenitors and precursors and mature red blood cells — can modulate immunity in different settings, including in infection, autoimmunity and cancer.

Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.

Understanding how cells differentiate to their final fates is a fundamental biological problem. Here, authors introduce MultiVeloVAE, a probabilistic framework that models gene expression and chromatin accessibility mechanistically, integrates multiple samples, accounts for bifurcations, and enables statistical testing over time.

The oncogene PIM1 regulates erythroblast enucleation via GTPase-dependent cytoskeletal remodeling and vesicle trafficking, independent of its canonical roles in cell proliferation and apoptosis.

Modelling definitive haematopoiesis in organoids has been challenging. A study now develops blood-generating heart-forming organoids that display heart muscle, vascular endothelium formation and definitive haematopoiesis. This organoid represents an in vitro model of human embryonic circulatory system development.

Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.