Gastrointestinal diseases articles from across Nature Portfolio

In 22 patients with auto-brewery syndrome, we found enrichment of gut bacterial genes in metabolic pathways associated with ethanol production. Treatment with faecal microbiota transplantation in one patient led to improvement in symptoms that correlated with changes in gut microbiota composition and improved metabolic function.

Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathways.

Protein is an essential nutrient in the human diet. This Review explores the fate of dietary protein in the gastrointestinal tract and its influence on colonic health and disease, providing insights into dietary protein metabolism, digestion, absorption, fermentation and the implications for colonic health.

Nutrition and dietary guidelines in gastrointestinal disorders vary in scope, rigour and recommendations, contributing to variations in practice. This Comment identifies nutrition and dietary guidelines for gastrointestinal disorders, namely chronic constipation, irritable bowel syndrome and inflammatory bowel disease, and examines the methodologies used to develop them.

In 22 patients with auto-brewery syndrome, we found enrichment of gut bacterial genes in metabolic pathways associated with ethanol production. Treatment with faecal microbiota transplantation in one patient led to improvement in symptoms that correlated with changes in gut microbiota composition and improved metabolic function.

Potassium-competitive acid blockers (P-CABs) overcome the limitations of proton pump inhibitors by providing faster, longer and stronger acid suppression without meal timing. Evidence shows that P-CABs are non-inferior for the management of mild erosive oesophagitis and superior for severe erosive oesophagitis, whereas data for non-erosive reflux disease remain conflicting.