Hormone receptors articles from across Nature Portfolio

Oestrogen receptor activation generates DNA breaks at regulatory elements that control gene expression. This study shows that APOBEC3B is required for these breaks, by deaminating cytosines within R-loops at oestrogen receptor-regulated enhancers.

Previous studies suggested that glycogen metabolism played a role in beiging of subcutaneous adipocytes. This work identifies a β-adrenergic–driven transcriptional program that promotes glycogen synthesis and turnover during thermogenic activation of adipocytes. PGC1α and estrogen-related receptors (ERRs) cooperatively sustain this program by regulating chromatin accessibility and gene expression.

This research reveals Gαs trafficking mechanisms, highlighting non-canonical pathways influencing endosomal GPCR signaling dynamics and implications.

A GPER1-PKA-Centrin pathway regulates centrosome numbers and centriole integrity in colorectal cancer cells in response to activation by endogenous, synthetic and xenoestrogen ligands.