Immunoblotting - Latest research and news

Latest Research and Reviews

Identification and characterization of binders to a cryptic and functional pocket in KRAS

In this work, Beyer and colleagues have utilized display screening technologies to comprehensively chart RAS proteins “druggability” and in doing so unravel a targetable ligand-induced pocket in RAS opening unprecedented anti-RAS targeted opportunities.
- Kim S. Beyer
- Jessica Klein
- Sauveur-Michel Maira
ResearchOpen Access02 Dec 2025 Nature Communications
Volume: 16, P: 10836
Modulation of the human GlyT1 by clinical drugs and cholesterol

GlyT1 critically regulates excitatory neurotransmission and has thus emerged as a therapeutic target for schizophrenia. This study delineates the binding sites of the clinically trialed drugs iclepertin and sarcosine and elucidates how cholesterol modulates GlyT1 activity.
- Na Li
- Yiqing Wei
- Yan Zhao
ResearchOpen Access11 Mar 2025 Nature Communications
Volume: 16, P: 2412
Host-specific targets of Histomonas meleagridis antigens revealed by immunoprecipitation
- Marcelo de Jesus Ramires
- Karin Hummel
- Ivana Bilic
ResearchOpen Access17 Feb 2025 Scientific Reports
Volume: 15, P: 5800
Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
- Max L. Valenstein
- Pranav V. Lalgudi
- David M. Sabatini
Research08 Jan 2025 Nature
Volume: 637, P: E11-E14
A consensus platform for antibody characterization

YCharOS is a consensus platform for antibody characterization developed through collaboration between academia and industry, enabling direct comparisons among antibodies that target a specific protein in three common applications.
- Riham Ayoubi
- Joel Ryan
- Carl Laflamme
Protocols17 Dec 2024 Nature Protocols
Volume: 20, P: 1509-1545
Pan msr gene deleted strain of Salmonella Typhimurium suffers oxidative stress, depicts macromolecular damage and attenuated virulence
- Raj Sahoo
- Tapan Kumar Singh Chauhan
- Manish Mahawar
ResearchOpen Access09 Dec 2023 Scientific Reports
Volume: 13, P: 21852