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Inhibitory RNA techniques are methods that use engineered RNA molecules to inhibit gene expression. Various approaches, including the expression or injection of microRNA, short inhibiting RNA, double-stranded or antisense RNA (e.g. morpholino oligomers), work via mechanisms that include transcript cleavage, sequestration and the inhibition of protein translation.
Here, the authors show that the Saccharibacteria Nanosynbacter lyticus strain TM7x elicits limited immune activation in the oral cavity, and binds to gingival epithelial cells via a T4P-dependent mechanism, leading to clustering of TLR2 receptors and subsequent caveolin-mediated endocytosis.
A single-cell resolution image-based genome-wide CRISPR screen, analysed with deep learning and random forest models, identified host factors regulating Ebola virus infection at distinct stages in the viral life cycle.
Blood specimen stabilization for the preservation of circulating tumor cells remains challenging. Here, the authors present a zwitterionic microgel platform for long-term hypothermic preservation of circulating tumor cells in the whole blood of cancer patients for noninvasive diagnostics.
Sumida et al. resolve the human T cell transcriptional response to type I interferon stimulation at high temporal resolution and reveal a genetic network controlling coinhibitory receptor expression.
Long noncoding RNAs regulate tissue-specific gene expression. Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs) and show a role of LEC-specific lncRNA, LETR1, in cell proliferation and migration.
