Membrane potential articles from across Nature Portfolio

Rod and cone signaling interactions via glutamate spillover are identified as mechanisms underlying ON and OFF light response polarity switches in retinal interneurons.

Single-cell intracellular recordings have been used as the primary tool for estimating driving forces across inhibitory receptors within the nervous system. Here, the authors present ORCHID as an all-optical method to measure inhibitory receptor driving forces in targeted brain cell types.

Whole-cell recordings of retinal ganglion cells responses to high-frequency stimulation (HFS) revealed that membrane depolarization mediates both inhibition and preferential activation. The results indicate that understanding ion-channel dynamics is crucial for improving HFS-based stimulation.

How starburst amacrine cell (SAC) dendrites transform concentrically distributed synaptic inputs into branch-specific directional outputs is not fully understood. Here the authors report that dendritic mGluR2 signaling and somatic Kv3-mediated shunting coordinately implement SAC dendritic direction selectivity.

A multiplane confocal microscope provides high-contrast volumetric imaging at kilohertz rates. This system enables imaging of densely expressed genetically encoded voltage indicators with cellular resolution in the mouse brain in vivo and in vitro.

A nanoscale field-effect transistor with a three-dimensional probe-presentation design can record intracellular potentials from single cells.

Using temperature-sensitive ion channels and magnetic nanoparticles attached to membranes of cells, the electrical activity in neurons can be controlled by an externally applied magnetic field.

Linked fluorescent proteins are used to visualize voltage in living mouse brains.