Metabolic diseases articles from across Nature Portfolio

Dysfunction of specialized adipose endothelial cells has been implicated in the metabolic derangements observed in individuals with obesity and type 2 diabetes. In this issue of Nature Metabolism, AlZaim et al. provide a single-cell molecular atlas of the human subcutaneous adipose tissue and highlight the possible contributions of adipose endothelial cells to adipose tissue pathology.

A study published in Nature Metabolism shows that extracellular vesicles from a small group of hypothalamic α-tanycytes direct diurnal feeding behaviour to maintain body weight and glucose homeostasis.

This Review synthesizes current evidence on the link between metabolic dysfunction and mental health outcomes, highlighting the importance of integrating metabolic screening into psychiatric care.

Dihydronicotinamide riboside, NRH, is a potent NAD precursor, yet its effects in vivo are poorly defined. Here the authors show that NRH prevents and treats diet-related metabolic damage, but these benefits can be halted by toxicity at high NRH doses

Heterochronic human serum in a microphysiological system of hiPSC-derived white adipose tissue–liver axis allows the study of aging and rejuvenation in humans.

This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesity.

This study identifies an autocrine role for hepatic FGF1, wherein its circadian rhythmicity synchronizes triglyceride secretion with activity. Disruption of this clock-regulated pathway impairs lipid homeostasis.

Amyloid fibrils formed by IAPP damage pancreatic beta cells, leading to type 2 diabetes. Here, the authors test nearly 2,000 variants of IAPP to map which mutations speed or block amyloid nucleation linked to type 2 diabetes.

Dysfunction of specialized adipose endothelial cells has been implicated in the metabolic derangements observed in individuals with obesity and type 2 diabetes. In this issue of Nature Metabolism, AlZaim et al. provide a single-cell molecular atlas of the human subcutaneous adipose tissue and highlight the possible contributions of adipose endothelial cells to adipose tissue pathology.

A study published in Nature Metabolism shows that extracellular vesicles from a small group of hypothalamic α-tanycytes direct diurnal feeding behaviour to maintain body weight and glucose homeostasis.

In pancreatic islets, α-cells secrete glucagon in response to hypoglycaemia. We report that neighbouring δ-cells regulate this process via a negative feedback loop. Hypoglycaemia enhances this intercellular crosstalk, resulting in impaired glucagon response and systemic counter-regulation. Targeting this feedback circuit between α- and δ-cells may help to prevent recurrent iatrogenic hypoglycaemia.

A new Series on ‘Nutrition’ is launched exploring how dietary components influence physiological processes and the complex links between dietary patterns and health determinants.