Microscopy articles from across Nature Portfolio

A transmissive Fourier ptychographic coherence scanning interferometry method provides accurate 3D morphology measurements of high aspect ratio and composite micro-trenches, enhancing both the signal-to-noise ratio and lateral resolution.

Dual-channel photoacoustic microscopy (DC-PAM) enables ultra-wide-field, high-speed, and high-resolution imaging, advancing whole-organ and whole-body studies in freely moving or physiologically active animals.

Tau phosphorylation was found to hinder the formation and protective functionality of tau envelopes against microtubule-severing enzymes, providing a potential explanation for microtubule destabilization observed in neuropathology.

Atomic force microscopy is used to investigate the adsorption and organization of ions on charged surfaces. Trivalent ions adopt complex networks, clusters and layers associated with overcharging, whereas divalent ions follow classical predictions.

Screening of 16 capsaicin chemical derivatives leads to the discovery of HMBB, the first mitochondrial inhibitor of the cell cycle protein AURKA in cellular models of breast cancer

We developed SmartEM, a method that integrates machine learning directly into the image acquisition process of an electron microscope. By allocating imaging time in a specific manner — scanning quickly at first, then rescanning only critical areas more slowly — we are able to accelerate the mapping of neural circuits up to sevenfold without sacrificing accuracy.

Vitrification of polymer solutions yields ultrasmall fluorescent polymer dots that combine dye-like size with nanoparticle brightness, enabling nanometre-precision live-cell tracking on standard microscopes.

Shaw prizewinner Wolfgang Baumeister is one of many international researchers recruited by Chinese institutes.

Achieving uniform, isotropic sub-micrometer-resolution imaging at high speed across large, cleared tissues has been a major challenge for light-sheet microscopy. To address this, we developed a cost-effective system that enables tenfold faster volumetric imaging with isotropic resolution of complex biological organs such as the mouse brain and cochlea.

Identifying individual cells and tracking their movements over time are two critically important tasks in bioimage analysis. We discuss a fresh wave of tools that push these techniques toward peak performance.