Myelopoiesis articles from across Nature Portfolio

Robin and colleagues describe a population of blood vessel-resident macrophages that function within the vasculature to maintain vascular and blood homeostasis in zebrafish and identify a conserved population of these cells in mice.

Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.

Here the authors identify adenophages, a previously unknown macrophage population present in exocrine glands in mice and humans. These cells are dependent on ILC2-derived GM-CSF and support glandular homeostasis.

Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene regulatory networks to identify lineage restriction within multilineage progenitors.

Using high-resolution live imaging in zebrafish, we discovered a population of macrophages residing within blood vessels, termed blood vessel-resident macrophages. These cells clear foreign particles and unfit cells from the circulation and rapidly respond to endothelial injury. Blood vessel-resident macrophages therefore constitute a dedicated immune population that safeguards blood and vascular integrity.

A new study uncovers how UBA1 mutations in VEXAS syndrome simultaneously promote myeloid inflammatory cell death and skew haematopoietic stem cells towards a myeloid lineage.

Clonal hematopoiesis of cells carrying an ASXL1 mutation promotes atherosclerosis. An unexpected function of ASXL1 — direct inhibition of IL-1 receptor and Toll-like receptor signaling — was lost by ASXL1 mutation, leading to prolonged inflammation. IRAK inhibitors reduced the atherosclerotic plaque size, implicating IRAK inhibitors in the therapies of cardiovascular diseases driven by ASXL1-associated clonal hematopoiesis.