Featured
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News & Views |
BRIGHTening growth hormone delivery
Growth hormone delivery with a biomimetic and programmed microneedle patch enhances therapeutic efficacy while prioritizing patient comfort and convenience.
- Suman Pahal
- & Thanh Duc Nguyen
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News & Views |
A swelling probe for nitric oxide
Nanoparticles containing superparamagnetic iron oxides linked by nitric oxide-cleavable linkers enable highly sensitive, selective and specific magnetic resonance imaging of nitric oxide in living mice.
- Mark D. Pagel
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News & Views |
Tackling food allergies by microbiome modulation
An oral immunotherapy consisting of an inulin-based gel loaded with an allergen successfully suppresses food allergy in mice.
- Benjamin J. Marsland
- & Nicola L. Harris
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Article |
A DNA origami device spatially controls CD95 signalling to induce immune tolerance in rheumatoid arthritis
A pH-responsive DNA origami device displays a precise geometric array of CD95 ligands to selectively induce activated immune cell death and elicit localized immune tolerance to alleviate rheumatoid arthritis.
- Ling Li
- , Jue Yin
- & Xiaoyuan Chen
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Article |
Mechanical checkpoint regulates monocyte differentiation in fibrotic niches
Myelofibrosis causes a pathological remodelling of the bone marrow, which becomes stiffer and more elastic, thus promoting the proliferation of proinflammatory monocytes and their differentiation into dendritic cells.
- Kyle H. Vining
- , Anna E. Marneth
- & David J. Mooney
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Article |
Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection
Early cancer detection typically involves invasive biopsies. Here the authors designed nanosensors that are depolymerized by disease-associated enzymes in vivo to produce fluorescent urinary signals for non-invasive early diagnosis.
- Jiaguo Huang
- , Xiaona Chen
- & Kanyi Pu
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Article |
Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance
Islet transplantation for diabetes treatment requires immunosuppression to control rejection. A microgel presenting Fas ligand with immunomodulatory properties is now shown to prolong the survival of allogeneic islet grafts in vivo.
- Devon M. Headen
- , Kyle B. Woodward
- & Haval Shirwan
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Article |
Quantitative self-assembly prediction yields targeted nanomedicines
Molecular simulations reveal the self-assembly of small molecules into nanoparticle drug carriers. Targeting of colon and liver cancer cells by the nanoparticles via kinase inhibitors is employed in anti-tumour therapy in vivo.
- Yosi Shamay
- , Janki Shah
- & Daniel A. Heller
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Article |
The development of bioresorbable composite polymeric implants with high mechanical strength
Metallic stents have been widely used in coronary angioplasty. Here, the authors develop a resorbable self-expanding stent from polymeric elastomers with high mechanical strength for coronary applications.
- Upma Sharma
- , Danny Concagh
- & Maria Palasis
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Article |
Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model
A hydrogel patch delivering a combination of gene, drug and phototherapy leads to complete tumour remission and the absence of tumour recurrence in a colon cancer mouse model.
- João Conde
- , Nuria Oliva
- & Natalie Artzi
Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation