Rheumatoid arthritis articles from across Nature Portfolio

Strategies to induce a durable pool of antigen-specific regulatory T cells in vivo are of great interest for the treatment of autoimmune diseases. Here, the authors present a dendritic cell (DC)-CD4⁺ T cell bispecific nanoparticle-based platform that delivers collagen II peptide and rapamycin and show that the formulation facilitates the spatial coupling of DCs and CD4⁺ T cells, promotes a tolerogenic microenvironment and alleviates symptoms of rheumatoid arthritis in a preclinical mouse model.

Alternative splicing may help explain genetic risk for joint diseases. Here, the authors generate cartilage and synovium sQTL maps, revealing tissue‑specific splicing variants and pinpointing effector genes for osteoarthritis, rheumatoid arthritis, and height

High-throughput and low-input quantitative citrullinome analysis integrated with deep learning reveals association between citrullinome landscape and rheumatoid arthritis severity, as well as rheumatoid arthritis-sera reactivity of identified citrullinated peptides.

The findings of the pivotal RESET-RA trial demonstrate the clinical benefits and safety of an implanted neuromodulation device that stimulates the vagus nerve for the treatment of rheumatoid arthritis.

Spatial transcriptomics analyses reveal that fibrogenic fibroblasts dictate treatment outcomes in rheumatoid arthritis.

Treatment-refractory rheumatoid arthritis is a major unmet clinical need, and the mechanisms that underlie resistance to therapy remain poorly understood. Using high-resolution spatial transcriptomics, we identified a spatiotemporal process of fibrogenic remodeling that is associated with failure to respond to treatment.

New research published in 2025 sheds light on the pre-clinical period that precedes the onset of classifiable rheumatoid arthritis, from risk factors to immunological events and opportunities to prevent the transition to clinical disease.

T helper 17 cells that lose IL-17 expression drive inflammation in a mouse model of chronic rheumatoid arthritis.