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Systems virology is the scientific discipline that integrates high-throughput molecular techniques and computational tools to study all aspects of viruses and viral diseases, in an effort to increase our understanding of viral pathogenesis and to improve diagnostics and therapeutics of viral diseases.
A genome language model, Protein Set Transformer, trained on viral datasets, uncovers evolutionary rules of protein content and organization driving precise virus identification, host prediction, and protein annotation for viral genomics and ecology.
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flaviviridae.
A metabolic modeling approach reveals druggable host cell pathways essential for viral replication across various viruses with minimal cytotoxicity. These findings highlight cellular metabolism as a promising target for antiviral therapy.
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tick cells to study its impact and reveal host antiviral responses and key restriction factors.
Functional systematic pseudotype virus-based analysis of the ability of diverse animal viruses to enter into a panel of well-characterized human cell lines shows a broad compatibility between animal virus receptor-binding proteins and human cell entry factors.
This month's Genome Watch highlights a new large-scale serological platform for the simultaneous detection of multiple human viruses in a single drop of blood.
