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Mutually reinforcing patterning mechanisms: authors' reply

Nature Reviews Molecular Cell Biology volume 12, page 533 (2011)Cite this article

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With regard to our recent Opinion article (Computational morphodynamics of plants: integrating development over space and time. Nature Rev. Mol. Cell Biol. 12, 265–273 (2011))1, we thank Álvarez-Buylla and colleagues for their correspondence (Mutually reinforcing patterning mechanisms. Nature Rev. Mol. Cell Biol. 23 Jun 2011 (doi:10.1038/nrm3079-c1))2 and for letting us know of the addition that they have made (of a redundant WEREWOLF (WER) activating factor, MYB23)3 to their model of epidermal pattern formation in response to the experimental evidence on WER expression discussed by Savage et al.4. This underlines a central point of our article: that iteration between computational models and experimental tests can lead to new or modified models that better predict experimental results.

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References

  1. Roeder, A. H. et al. Computational morphodynamics of plants: integrating development over space and time. Nature Rev. Mol. Cell Biol. 12, 265–273 (2011).

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  2. Álvarez-Buylla, E., Benítez M. & Espinosa-Soto, C. Mutually reinforcing patterning mechanisms. Nature Rev. Mol. Cell Biol. 23 Jun 2011 (doi:10.1038/nrm3079-c1).

  3. Benítez, M., Espinosa-Soto, C., Padilla-Longoria, P. & Alvarez-Buylla, E. R. Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: a dynamic spatial model. BMC Syst. Biol. 2, 98 (2008).

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  4. Savage, N. S. et al. A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis. PLoS Biol. 6, e235 (2008).

    Article  Google Scholar 

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Authors and Affiliations

  1. Vijay Chickarmane and Elliot M. Meyerowitz are at the Division of Biology 156-29, Adrienne H. K. Roeder, Paul T. Tarr, Cory Tobin, Xiaolan Zhang, California Institute of Technology, 1200 E. California Blvd, Pasadena, California 91125, USA.,

    Adrienne H. K. Roeder, Paul T. Tarr, Cory Tobin, Xiaolan Zhang, Vijay Chickarmane & Elliot M. Meyerowitz

  2. Alexandre Cunha is at the Center for Advanced Computing Research MC 158-79, California Institute of Technology, 1200 E. California Blvd, Pasadena, California 91125, USA.,

    Alexandre Cunha

Authors
  1. Adrienne H. K. Roeder
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  2. Paul T. Tarr
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  3. Cory Tobin
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  4. Xiaolan Zhang
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  5. Vijay Chickarmane
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  6. Alexandre Cunha
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  7. Elliot M. Meyerowitz
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Corresponding authors

Correspondence to Adrienne H. K. Roeder or Elliot M. Meyerowitz.

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The authors declare no competing financial interests.

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Roeder, A., Tarr, P., Tobin, C. et al. Mutually reinforcing patterning mechanisms: authors' reply. Nat Rev Mol Cell Biol 12, 533 (2011). https://doi.org/10.1038/nrm3079-c2

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