Correction to: Scientific Reports https://doi.org/10.1038/s41598-017-00629-3, published online 03 April 2017
This article contains errors. As a result of errors during figure assembly, a TNF-α image panel mistakenly displays a duplication of an IL-1β image panel in Figure 3E. In Figure 4E, partial overlaps are shown for an image from the CD68 condition that was mistakenly used for the TNF-α condition and an image for the MPO group that was mistakenly used for the CD68 condition.
pri-miR-9-BMSCs could inhibit the local inflammatory response. The expressions of pro-inflammatory cytokines(IL-1β, IL-6, TNF-α, and MPO), NF-κB proteins (p-P65, P50) and CD68 were significantly decreased by pir-miR-9-BMSCs. On the contrary, the expressions of superoxide dismutase (SOD1 and SOD2) and anti-inflammatory proteins (IκBα and IκBβ) were significantly increased by pir-miR-9-BMSCs, compared with SAP, SAP + PBS, BMSCs, or TuD-BMSCs groups by gPCR (A,B), Western-blot (C,D) and IHC (E,F). Data are shown as mean ± SD for at least 3 separate experiments. %%P < 0.01, compared with NC, #p < 0.05, ##p < 0.01 and ###p < 0.001, compared with NC, +p < 0.05, ++p < 0.01 and +++p < 0.001, compared with SAP, *p < 0.05 and **p < 0.01, compared with SAP + PBS, @p < 0.05 and @@p < 0.01, compared with BMSCs, $p < 0.05 and $$p < 0.01, compared with Empty-virus BMSCs, †p < 0.05, ††p < 0.01 and †††p < 0.001, compared with TuD-BMSCs by using paired t test. gPCR, General PCR, IHC, immunohistochemistry.
miR-9 could antagonize the local inflammatory response. The expressions of IL-1β, IL-6, TNF-α, MPO, p-P65, P50, and CD68 were significantly decreased by miR-9a-5p agomir. Inversely, the expressions of SOD1, SOD2, IκBα, and IκBβ were significantly increased by miR-9a-5p agomir, compared with SAP + PBS or miR-9a-5p control group, by gPCR (A,B), Western-blot (C,D) and IHC (E,F). Data are shown as mean ± SD for at least 3 separate experiments. %P < 0.05, compared with NC, #p < 0.05 and ###p < 0.001, compared with NC, *p < 0.05, **p < 0.01 and ***p < 0.001, compared with SAP + PBS, &p < 0.05, &&p < 0.01, and &&&p < 0.001, compared with miR-9a-5p control by using paired t test. SOD, Superoxide Dismutase, gPCR, General PCR, IHC, immunohistochemistry.
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Qian, D., Wei, G., Xu, C. et al. Author Correction: Bone marrow-derived mesenchymal stem cells (BMSCs) repair acute necrotized pancreatitis by secreting microRNA-9 to target the NF-κB1/p50 gene in rats. Sci Rep 15, 31847 (2025). https://doi.org/10.1038/s41598-025-16464-w
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DOI: https://doi.org/10.1038/s41598-025-16464-w
