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Ciofani et al., discuss the unique medical and pharmaceutical challenges in maintaining and supplying medical care for crews involved for human space missions beyond Low Earth Orbit, such as to the Moon and Mars. They highlight opportunities for repurposing existing innovative technologies and biomedical advances to support crew health during long-duration missions.
Gries et al. comprehensively review the pathophysiological link between MASLD and the various heart failure subtypes. Their discussion highlights preventative and therapeutic co-management strategies for patients with both conditions.
Gupta et al. discuss the epidemiology and burden of major circulating arboviral diseases in India, touching on diagnosis, treatment, and preventative measures. They highlight key research and policy gaps, along with direction for future research, to improve surveillance and control measures.
Kohabir et al. review recent advances in CRISPR-based diagnostics aimed at achieving single-nucleotide fidelity for clinical applications. By dissecting strategies in gRNA design, effector selection, and reaction conditions, the authors highlight how these innovations can support precise and accessible genetic testing at the point-of-care.
Boeckmans et al. discuss the importance of healthcare providers fully engaging with people with Metabolic dysfunction-associated steatotic liver disease (MASLD) and actively working with them to improve their metabolic health. They propose areas to focus on and provide a practical guide to healthcare practitioners in this area.
Eisinger-Mathason et al. examine how data linkage transforms healthcare research by integrating diverse datasets. They also discuss privacy-preserving methods and challenges related to data quality and privacy.
Sridhar et al. review the opportunities that mobile health technologies offer to improve the care of patients with cardiac arrhythmias. The current status, challenges, and future opportunities to use these technologies to predict, screen, diagnose, and manage of cardiac arrhythmias are highlighted.
Ng, Chaturvedi et al. discuss established, emerging, and promising biomarkers related to preeclampsia. They highlight novel approaches for screening these biomarkers at the point of care, aiming to democratize testing and reduce the burden of the disease.
Vasudevan et al. discuss optical melanometry as a tool for objective, quantitative evaluation of skin pigmentation in studies addressing pulse oximeter racial disparity. The authors analyze research on commercial melanometer accuracy, discuss best practices for implementation and highlight promising future research directions.
Lauffer et al. discuss the possibilities that antisense oligonucleotide (ASO) approaches can bring to treating rare genetic diseases. The authors outline considerations and barriers to their implementation, and how these might be overcome.
Koh, Papanikolaou et al. discuss the application of artificial intelligence in cancer imaging. The authors highlight opportunities for exploiting machine learning algorithms in this field, and outline barriers in their implementation and how these might be addressed.