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Covalent DNA tagging of cysteine residues enhances protein capture and slows the passage of proteins through a silicon nitride nanopore, yielding distinctive electrical signatures for the rapid classification of proteins.
Integrated scanning probe techniques in combination with first-principles theory unveil the crystallization of electron polarons into quasi-one-dimensional polaron superlattices in individual polypentacene molecules.
Memristor arrays based on molecular crystal with van der Waals-linked cages are fabricated, enabling ultralow energy switching, high endurance and seamless integration into neuromorphic computing hardware.
Self-assembled multidomain supramolecular peptide hydrogels that engage in dynamic covalent bonding with small-molecule drugs and biologics are shown to offer sustained release, extend the activity, and maintain safe and potent drug levels in vivo.
Metasurface optical modulators with silicon/organic hybrid nanostructures are demonstrated to achieve >Gbit s−1 data modulation with complementary metal–oxide–semiconductor-compatible driving voltages.
Through binding mitochondrial ATP synthase, engineered nanomedicines rejuvenate aged bone stem cells and restore osteogenesis, reversing osteoporosis in mice and offering a potential senolytic therapy for skeletal ageing.
Acoustically activatable nanocarriers made by incorporating 5% sucrose into liposomes release drug with low-intensity ultrasound, providing a readily clinically translatable system for both central and peripheral noninvasive neuromodulation.
A single adaptive neuromorphic vision device is reported to emulate four high-order visual neuronal dynamics, enabling a highly efficient and compact artificial general vision intelligence system towards dynamic scenarios.
Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA–lipid nanoparticles while enabling high RNA expression.
Polariton-mediated photochemical charge transfer can be identified and quantified in a properly designed photonic system using momentum-resolved ultrafast optical techniques.
Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA-lipid nanoparticles while enabling high RNA expression.
Room-temperature nonlinear Hall effect has been observed in wafer-scale (001)-oriented SnTe thin films, enabling wireless, ultrabroadband and low-power rectification at zero electrical bias and zero magnetic field.
Single, self-amplifying RNA molecules condensed by an oppositely charged polyelectrolyte self-assemble into compact globular nanoparticles that can be used as vaccines to generate potent immunological responses at low doses.
Intravenous interleukin-10 messenger RNA nanoparticles enhance immune responses in preclinical tumour models, promoting T cell activity and dendritic cell maturation, as well as improving survival and tumour eradication rates, with limited interleukin-10-induced systemic toxicity.
Dynamic Kerr microscopy enables the tracking of the two-step melting of a magnetic skyrmion lattice from a two-dimensional solid through an intermediate hexatic regime to an isotropic liquid and provides direct insights in the occurrence and dynamics of lattice dislocations, the defects that mediate melting.
A mix-and-go system enables the rapid prototyping of antibody formulations, allowing control of their orientation on the surface of LNPs for specific cell targeting, significantly improving the ex vivo and in vivo deliveries of mRNA.
An abiotic information ratchet mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions.
