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Volume 18 Issue 10, October 2024

Fluorescence-lifetime image scanning microscopy

Integrating a single-photon avalanche detector (SPAD) array into a confocal laser scanning microscope yields a twofold increase in the localization accuracy for single-molecule localization microscopy. The cover shows an artistic impression of the SPAD array detector with microlenses, where the two disks/shaded Gaussians depict the emission of two different fluorescent molecules hitting the detector array.

See Radmacher et al.

Image: Alexey Chizhik. Cover design: Bethany Vukomanovic

News & Views

  • Two independent demonstrations of room-temperature Bose–Einstein condensation of light in semiconductor optical microcavities with embedded quantum wells may pave the way for harnessing the effect for practical applications, such as high-power, single-mode emission from large-aperture devices.

    • Alejandro Fainstein
    • Gonzalo Usaj
    News & Views

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  • Ultrashort laser light–matter interactions can create unique virtual quantum states. Researchers have now revealed this phenomenon in solution-grown semiconductor nanoplatelets using visible light.

    • Sheikh Rubaiat Ul Haque
    • Yuki Kobayashi
    News & Views
  • Optical nanoantenna field enhancement is hampered by material- and size-dependent losses. Researchers have now made an atomic antenna using the controlled formation of an isolated germanium vacancy colour centre in diamond, which enables giant near-field optical enhancement and which can detect and control nearby charges and induce energy transfer.

    • Stefania Castelletto
    • Mario Agio
    News & Views
  • Three-dimensional, label-free optical images of a complex volumetric sample can now be obtained at a 1-Hz volumetric frame rate, thanks to the use of ultrafast camera measurements and sparse representation of the sample optical response.

    • Thomas Chaigne
    News & Views
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Review Articles

  • This Review provides an overview of the most recently developed quantum imaging systems, highlighting the nonclassical properties of sources, such as bright squeezed light, entangled photons and single-photon emitters that enable their functionality.

    • Hugo Defienne
    • Warwick P. Bowen
    • Daniele Faccio
    Review Article
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Articles

  • Using a gas–solid mixture approach, researchers used a transparent, scintillating nanoporous material for real-time detection of 85Kr and 3H, two pure beta emitters. They also simultaneously measure a mixture of them. The broadly applicable approach may be useful for nuclear industry and environmental safeguarding.

    • Raphael Marie-Luce
    • Pavlo Mai
    • Christophe Dujardin
    Article Open Access
  • An optical accelerator is designed to leverage a multiple-scattering cavity to passively induce optical nonlinear random mapping with a continuous-wave laser at a constant low power (~21 mW), providing a new avenue for optical computing.

    • Fei Xia
    • Kyungduk Kim
    • Hui Cao
    Article Open Access
  • Multiple scattering capable of synthesizing programmable linear and nonlinear transformations concurrently at low optical power in the order of milliwatts continuous-wave power for optical computing is demonstrated, paving the way for ultra-efficient, low-power all-optical neural networks.

    • Mustafa Yildirim
    • Niyazi Ulas Dinc
    • Christophe Moser
    Article Open Access
  • Photon Bose–Einstein condensation is observed in a semiconductor laser, where thermalization and condensation of photons occur using an InGaAs quantum well and an open microcavity. The distinction between regimes of photon Bose–Einstein condensation and conventional lasing are clearly identified.

    • Ross C. Schofield
    • Ming Fu
    • Rupert F. Oulton
    Article Open Access
  • Bose–Einstein condensation of photons is demonstrated in a large-aperture electrically driven InGaAs vertical-cavity surface-emitting laser diode at room temperature. The observed photon Bose–Einstein condensate exhibits the fundamental transversal optical mode at a critical phase-space density.

    • Maciej Pieczarka
    • Marcin Gębski
    • Tomasz Czyszanowski
    Article Open Access
  • Based on the acquisition of a multi-spectral reflection matrix at a high frame rate, a fully digital microscope overcomes aberrations and multiple scattering to provide a three-dimensional image of an ex vivo opaque cornea at a resolution of 0.29 μm and 0.5 μm in the transverse and axial directions, respectively.

    • Paul Balondrade
    • Victor Barolle
    • Alexandre Aubry
    Article
  • Researchers show that atom-like dipoles based on germanium vacancy centres in diamond may be useful as antennas, exhibiting million-fold near-field optical intensity enhancement. These antennas are used to detect and control the charge state of nearby carbon vacancies.

    • Zixi Li
    • Xinghan Guo
    • Alexander A. High
    Article
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Amendments & Corrections

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