Articles in 2013

Kevin Ryan and colleagues have identified a new route through which the tumour suppressor protein p53 induces apoptosis.

Two recent papers have provided evidence that the mitochondrial sirtuin SIRT4 exerts tumour suppressive activities by repressing glutamine metabolism.

This paper describes a new method for viewing multidimensional, single-cell mass cytometry data.

Several recent reports in the popular press have indicated that the benefits of exposure to sunlight might outweigh the risks of developing skin cancer.

Genome sequencing of 57 prostate tumours has revealed the frequent occurrence of complex, chained genomic rearrangements (termed 'chromoplexy') that result in deletions or rearrangements of cancer genes. Furthermore, prostate cancers may undergo multiple rounds of chromoplexy throughout tumour evolution.

Awareness is increasing that progesterone signalling via the progesterone receptor (PR) has important roles in breast biology and breast cancer. Understanding more about this pathway may lead to new therapeutic and preventive options for breast cancer.

Over the past decade, our understanding of neuroblastoma has advanced tremendously. This Review discusses the key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools to bring these promising scientific advances into the clinic.

A new study has used a computational drug screening approach to identify RAS-binding compounds that can inhibit downstream signalling from oncogenic RAS isoforms.

Two recently published papers have found that the disruption of microRNA maturation might contribute to cancer-related phenotypes.

The domestic laying hen is the only non-human animal that spontaneously develops ovarian cancer with a high prevalence. This Opinion article discusses how the hen may be used as a potential model of human ovarian cancer, and the advantages and disadvantages of this system.

A screen has prospectively identified a resistance mutation in the androgen receptor (AR) that is selected for during treatment with the AR antagonist enzalutamide, andin silicomodelling has suggested a mechanism behind the resistance, which may be able to be overcome using a novel compound.

Allosteric disulphide bonds regulate the function of the mature proteins in which they reside. This Opinion article discusses the progress in our ability to identify and disrupt allosteric disulphide bonds and the potential therapeutic value of targeting these bonds in cancer.

Two papers published inSciencedescribe small molecules that inhibit mutant forms of IDH1 and IDH2.

Two new studies describe molecular classifications of colorectal cancer that show predictive value for patient outcome and therapy response.

Two papers published inScience Translational Medicinediscuss the development of prognostic models for breast cancer, based on the 'wisdom of the crowds' challenge environment.

Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Recent deep sequencing studies have shown that nearly 20% of human tumours harbour mutations in GPCRs. This Analysis article reviews these findings and the indications that G proteins, GPCRs and their signalling pathways represent novel therapeutic targets for cancer prevention and treatment.