Research Highlights in 2012

A role for RAB10 in guiding ER dynamics.

Scs2, Scs22, Ist2, Tcb1, Tcb2 and Tcb3 tether the ER to the plasma membrane in yeast.

Monoubiquitylation at Lys147 keeps RAS active by reducing its sensitivity to GAPs.

The SNARE protein STX17 is recruited specifically to completed autophagosomes to mediate fusion with lysosomes.

KIF4, condensin and topoisomerase IIα function to shape mitotic chromosomes.

YAP restricts the proliferation of intestinal stem cells by antagonizing WNT signals.

The methyltransferase G9A represses adipogenesis by inhibiting PPARγ and promoting WNT10A expression.

The identification of a ribosome-bound complex that degrades stalled proteins.

Hog1 minimizes collisions between the transcription and replication machinery during osmostress.

Autophagy regulates microRNAs by degrading DICER and AGO.

A crucial role for the ubiquitin–proteasome system in regulating chloroplast plasticity by controlling protein import.

Histones are anchored to lipid droplets by Jabba.

Dynamics of histone H2A.Z localization at active promoters during the cell cycle.

Substrate stiffness regulates collective cell migration.

Hedgehog signalling regulates autophagy.

Two studies explore the basis of uniparental mitochondrial DNA (mtDNA) inheritance and the feasibility of replacing mutant mtDNA from oocytes.

Methylation and uridylation regulate microRNA biogenesis.

STAT3 inhibits autophagy by binding to PKR.

Super-resolution microscopy reveals a conserved higher-order organization in pericentriolar material.

The asymmetric modification of sister histones can alter the nucleosome functional state.