Under the Lens

This month’s Under the Lens discusses new strategies to image the spatial geography of microbial communities.

This month’s Under the Lens discusses a few of the growing number of recent molecular simulation studies that have made substantial contributions towards our mechanistic understanding of the spike protein of SARS-CoV-2.

This month’s Under the Lens discusses how recent advanced microscopy studies have provided insights into key target-search mechanisms that allow the recombinase RecA to rapidly and efficiently find homology for DNA repair.

This month’s Under the Lens discusses how recent advances in understanding the spatial integration of transcription and splicing sites have shed light on the mechanism that ensures monogenic antigen expression in trypanosomes.

This month’s Under the Lens discusses the potential of in silico feedback control applied to individual microbial cells, highlighting its use for study of single-cell dynamics and patterning behaviours.

This month’s Under the Lens discusses the application of the quantitative image analysis software BiofilmQ to understand antibiotic-induced changes in Vibrio cholerae biofilms at single-cell resolution.

This month’s Under the Lens discusses how combining cryo-electron tomography with cross-linking mass spectrometry has allowed elucidation of the mechanisms of transcription-coupled translation in bacteria.

This month’s Under the Lens discusses a recent advance in the imaging of anaerobic gut bacteria using nanaerobic growth conditions.

This month’s Under the Lens discusses the application of high-speed atomic force microscopy to image fragile bacterial membrane vesicles by briefly touching them with a gentle tapping force, revealing species-specific heterogeneity in membrane vesicle size distribution linked to biological function.

This month’s Under the Lens discusses recent advances in high-resolution imaging of bacterial membrane proteins within intact liposomes by electron cryomicroscopy.

This month’s Under the Lens discusses dual-view light-sheet microscopy and how its use has revealed the dynamics of bacterial biofilm development, a fundamental process found in bacteria.

This month’s Under the Lens discusses how structural studies of the SARS-CoV-2 spike glycoprotein might guide a path towards a vaccine.

This month’s Under the Lens discusses recent advances in spatial metabolomics and light-sheet microscopy for imaging the biogeography of host–microbiota interactions.

This month’s Under the Lens discusses the use of single-molecule tracking in bacteria to study how CRISPR–Cas systems accurately and efficiently identify specific DNA sequences within viruses and other mobile genetic elements, thereby preventing their invasion.

This month’s Under the Lens discusses the application of light sheet fluorescence microscopy to observe the intestinal microbiota of live zebrafish, revealing unexpected host–microorganism interactions.

This month’s Under the Lens explores how recent developments in sample preparation are aiding and advancing the imaging of host–microorganism interactions.

This month’s Under the Lens discusses how 3D fluorescence microscopy techniques are furthering the study of dynamic spatial organization and confinement in bacterial cells.

This month’s Under the Lens discusses the use of a novel label-free imaging method to study pilus dynamics at high spatial and temporal resolution.

This month’s Under the Lens discusses progress towards bridging the resolution gap in correlative super-resolution light and electron microscopy, and highlights its application for visualizing bacterial infections.

This month’s Under the Lens discusses the use of single-molecule tracking to study the effects and response of bacterial cells exposed to antibiotics.