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In this Tools of the Trade article, Yu Zheng describes the design of a far-red dopamine sensor that enables the simultaneous monitoring of multiple neurotransmitters in the brain.
In this study, flagellin, a highly conserved microbe-associated molecular pattern that increases after meals, is shown to activate TLR5 receptors expressed by neurpod cells in the colonic epithelium that signal to the brain via PYY release and vagal activation and influence feeding behaviour.
The diverse sensory input provided by physically and socially enriched environments is shown in mice to increase sensory integration and responsiveness to environmental stimuli, whereas social isolation produced the opposite effects.
Single-nucleus RNA sequencing reveals early cellular responses in young atheletes exposed to repetitive head impacts that may lead to neurodegeneration.
A new study finds that grid cells track a mouse’s position in local reference frames instead of a global frame of reference in a path integration task.
In this Journal Club, Olivia Gold discusses a 2003 study showing in rats that respiratory depression caused by the synthetic opioid fentanyl could be pharmacologically reversed without compromising its analgesic effects.
Long non-coding RNAs are abundant in the brain, where they are proposed to regulate numerous processes. In this Review, Mattick and colleagues describe our current understanding of their mechanisms of action, focusing on their contributions to enhancer function and the organization of specialized intracellular domains, and consider their roles in brain function and dysfunction.
Endocannabinoids are key mediators of affective behaviour, but the neural mechanisms that underlie these effects are only beginning to be elucidated. Here, Loomba and Patel review advances in understanding of the cellular and circuit-level mechanisms underlying endocannabinoid control of anxiety-like behaviour and stress adaptation and provide perspectives on unifying models and the therapeutic implications of endocannabinoid signalling.
In animal models, transient high-frequency oscillations in synchronized neural activity, known as ripples, have been linked to memory. Reithler et al. assess the current evidence for a contribution of ripples to human memory processes and suggest that examining the underlying spike content of ripples could enable researchers to decipher their functions.
As an animal moves within its environment, self-motion signals are generated by the inner ear vestibular organs and the retina and transmitted to the CNS. In this Review, Mao and Gu describe how these multisensory signals are processed and integrated by the brain to enable self-motion perception and aid navigation.
