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De novo designed protein guiding targeted protein degradation

Targeted protein degradation in bacteria typically requires fusion with tags or chemical degraders. Here, authors developed GPlad, a tunable system using designed guide proteins and arginine kinase to degrade diverse proteins in E. coli without the need for exogenous degraders or protein fusions.

Zhendong Li
Gan Qiao
Liming Liu
ResearchOpen Access17 Jul 2025
Nature Communications

Volume: 16, P: 1-18
The selection process of licensing a DNA mismatch for repair

Cryo–EM reconstructions and atomic models reveal the mechanism of MutS–MutL DNA mismatch recognition and repair initiation.

Rafael Fernandez-Leiro
Doreth Bhairosing-Kok
Meindert H. Lamers
Research05 Apr 2021
Nature Structural & Molecular Biology

Volume: 28, P: 373-381
Radioactivity in Man, Beast and Food

A. T. KREBS
Research17 Feb 1962
Nature

Volume: 193, P: 622-624
Formation of the 3′ end of histone mRNA by post-transcriptional processing

P. A. Krieg
D. A. Melton
Research08 Mar 1984
Nature

Volume: 308, P: 203-206
MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair

The mechanics of MMR strand specific excision that begins at a distant ssDNA break are not yet clear. Here the authors have used multiple single molecule imaging techniques to visualize the behavior of MMR components on mismatched DNA substrates and reveal an exonuclease-independent mechanism for E.coli MMR.

Jiaquan Liu
Ryanggeun Lee
Richard Fishel
ResearchOpen Access22 Nov 2019
Nature Communications

Volume: 10, P: 1-15
A Selenium Cycle in Nature?

A. SHRIFT
Research28 Mar 1964
Nature

Volume: 201, P: 1304-1305
Alpha-Particle Activity and Free Radicals from Tobacco

ERNEST MARSDEN
MICHAEL A. COLLINS
Research08 Jun 1963
Nature

Volume: 198, P: 962-964
Effect of Oxygen in Mammalian Cells Sensitized to Radiation by Incorporation of 5-Bromodeoxyuridine into the DNA

R. M. HUMPHREY
W. C. DEWEY
A. CORK
Research20 Apr 1963
Nature

Volume: 198, P: 268-269
Alpha-Radioactivity of Human Blood

V. HASSON
R. D. CHERRY
Research07 May 1966
Nature

Volume: 210, P: 591-593
Interlocus Specificity for Chemical Mutagens in Aspergillus nidulans

THOMAS ALDERSON
A. M. CLARK
Research07 May 1966
Nature

Volume: 210, P: 593-595
Genomic mismatch scanning: a new approach to genetic linkage mapping

Stanley F. Nelson
John H. McCusker
Patrick O. Brown
Research01 May 1993
Nature Genetics

Volume: 4, P: 11-18
A role for the bacterial GATC methylome in antibiotic stress survival

James Collins and colleagues explore the role of the bacterial epigenome in antibiotic stress survival. They find that Escherichia coli survival under antibiotic pressure is strongly compromised in the absence of adenine methylation at GATC sites, suggesting that targeting adenine methylation might be a viable approach to enhance antibiotic activity.

Nadia R Cohen
Christian A Ross
James J Collins
Research21 Mar 2016
Nature Genetics

Volume: 48, P: 581-586
Electron-beam Dosimetry using the Radiation-induced Fluorescence of Polyethylene

D. A. RADOVSKY
H. BRUMBERGER
Research01 Nov 1967
Nature

Volume: 216, P: 469-470
The peripatetic fossils: part 3

The articles printed below are by co-authors of some of the papers called into doubt by Talent. Two are by close colleagues of Gupta at the Centre of Advanced Study in Geology at Panjab University.

A. D. Ahluwalia
Comments & Opinion07 Sept 1989
Nature

Volume: 341, P: 13-15
The case of the peripatetic fossils

Through the activities of one Indian scientist, the palaeontological literature on the Himalayas has become shot through with disinformation.

John A. Talent
Comments & Opinion20 Apr 1989
Nature

Volume: 338, P: 613-615
The multifaceted mismatch-repair system

Mismatch repair improves the fidelity of DNA replication and affects recombination, DNA-damage signalling, apoptosis and certain cell-type-specific processes of DNA metabolism. Intriguingly, the same system that guards genomic instability on the one hand contributes to cell death on the other.

Josef Jiricny
Reviews12 Apr 2006
Nature Reviews Molecular Cell Biology

Volume: 7, P: 335-346
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

Sean M. Baker
Annemieke W. Plug
R. Michael Liskay
Research01 Jul 1996
Nature Genetics

Volume: 13, P: 336-342
Local Ground-Level Air Concentrations of Lead-210 at Winchester, Massachusetts

B. SHLEIEN
A. G. FRIEND
Research07 May 1966
Nature

Volume: 210, P: 579-580
N⁶-methyl-adenine: an epigenetic signal for DNA–protein interactions

The authors review the fundamental roles of N⁶-methyl-adenine in bacteria. In γ-proteobacteria, Dam methylation facilitates DNA–protein interactions involved in chromosome segregation, mismatch repair, transposition, and the epigenetic control of gene expression. In α-proteobacteria, the CcrM methylase is an important cell-cycle regulator.

Didier Wion
Josep Casadesús
Reviews01 Mar 2006
Nature Reviews Microbiology

Volume: 4, P: 183-192
Continuous culture of Escherichia coli, under selective pressure by a novel antimicrobial complex, does not result in development of resistance

Lilit Tonoyan
Gerard T. A. Fleming
Vincent O’Flaherty
ResearchOpen Access20 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Functional interactions and signaling properties of mammalian DNA mismatch repair proteins

A Bellacosa
Reviews30 Oct 2001
Cell Death & Differentiation

Volume: 8, P: 1076-1092
Structure of ‘Complex’ Phospholipids

A. J. DE KONING
Research21 Dec 1963
Nature

Volume: 200, P: 1211-1212
Selenium Content of Fresh Eggs from Normal and Dystrophic Chickens

H. H. TAUSSKY
A. WASHINGTON
A. T. MILHORAT
Research21 Dec 1963
Nature

Volume: 200, P: 1211
Meningococcal genome dynamics

To evade the immune system, the meningococcus generates genetic variants and balances this genome instability with genome repair. Tonje Davidsen and Tone Tønjum review the dynamics of the meningococcal genome and contrast its unique DNA-repair profile with that of the model organismEscherichia coli.

Tonje Davidsen
Tone Tønjum
Reviews01 Jan 2006
Nature Reviews Microbiology

Volume: 4, P: 11-22
Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

Seongman Kang
Adam Jaworski
Robert D. Wells
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 213-218
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4 due to reduced activation of innate immune signaling.

Simon Schroeder
Christin Mache
Christian Drosten
ResearchOpen Access07 Sept 2021
Nature Communications

Volume: 12, P: 1-13
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

Brian Hendrich
Ulrike Hardeland
Adrian Bird
Research16 Sept 1999
Nature

Volume: 401, P: 301-304
The peripatetic fossils: part 5

Replyingto articles published in last week's Nature, Talent re-asserts that V. J. Gupta is responsible for corrupting the palaeontological literature on the Himalayas.

John A. Talent
Comments & Opinion01 Feb 1990
Nature

Volume: 343, P: 405-406
Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells

The most recent class of base editors utilize DddAtox, a deaminase domain that can act upon double-stranded DNA. Here the authors target DddAtox fragments and a FokI-based nickase to the human CIITA gene by fusing these domains to arrays of engineered zinc fingers; they also identify a variety of DddAtox orthologues.

Friedrich Fauser
Bhakti N. Kadam
Jeffrey C. Miller
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Bacterial DNA excision repair pathways

To maintain genome integrity and ensure cell survival, bacteria have evolved several DNA repair pathways to repair different types of DNA damage and non-canonical bases, including strand breaks, nucleotide modifications, cross-links, mismatches and ribonucleotide incorporations. In this Review, Wozniak and Simmons provide a contemporary discussion of the excision-based mechanisms bacteria use to repair the diverse set of lesions they encounter.

Katherine J. Wozniak
Lyle A. Simmons
Reviews24 Feb 2022
Nature Reviews Microbiology

Volume: 20, P: 465-477
Therapeutic targeting of mismatch repair-deficient cancers

This comprehensive Review describes the biological function of the mismatch repair (MMR) machinery, the genomic sequelae of defects in this machinery and the roles of hereditary or sporadic MMR deficiency in cancer predisposition and/or tumour development. The authors also discuss the clinical implications of MMR deficiency with a specific focus on diagnostic approaches, therapeutic strategies and mechanisms of resistance to immune-checkpoint inhibitors.

Paul Johannet
Benoit Rousseau
Luis A. Diaz Jr.
Reviews10 Jul 2025
Nature Reviews Clinical Oncology

Volume: 22, P: 734-759
The Theory of Determinants

T. J. I'A. B.
Books & Arts04 Aug 1904
Nature

Volume: 70, P: 315-316
Single gold-bridged nanoprobes for identification of single point DNA mutations

The identification of single point mutations is an important step toward personalizing detection and treatment. Here the authors design a gold-bridged nanoparticle for sensing MutS affinities to point mutations, and compile an atlas of the affinity data for detecting BRCA1 mutations in cell lines.

Xingyi Ma
Sojin Song
Sang Jun Sim
ResearchOpen Access19 Feb 2019
Nature Communications

Volume: 10, P: 1-13
The Magnetic Storm and Solar Disturbance of June 17, 1915

A. L. CORTIE
Research24 Jun 1915
Nature

Volume: 95, P: 450-451
New Inorganic Chemistry

E. A. V. EBSWORTH
Research03 Dec 1966
Nature

Volume: 212, P: 1018-1019
Wind and the Direction of Nocturnal Songbird Migration

S. A. GAUTHREAUX jun.
K. P. ABLE
Research31 Oct 1970
Nature

Volume: 228, P: 476-477
Earthworms

HY. F. WALKER
Research27 Mar 1884
Nature

Volume: 29, P: 503
Thermodynamic Equilibrium

G. A. ELLIOTT
Research26 May 1951
Nature

Volume: 167, P: 865-866
“The White Water”

A. R. PALMER
Research29 Jan 1920
Nature

Volume: 104, P: 563
The Theory of Magnetic Action upon Light

A. B. BASSET
Research12 Dec 1895
Nature

Volume: 53, P: 130
The complete genome sequence of the Gram-positive bacterium Bacillus subtilis

F. Kunst
N. Ogasawara
A. Danchin
ResearchOpen Access20 Nov 1997
Nature

Volume: 390, P: 249-256
DNA motifs that sculpt the bacterial chromosome

Non-coding DNA motifs play a central part in the bacterial cell cycle. El Karoui and colleagues review the roles of such motifs in replication, DNA segregation, DNA repair, cell division and DNA uptake, and explain how their distribution can be analysed quantitatively.

Fabrice Touzain
Marie-Agnès Petit
Meriem El Karoui
Reviews16 Dec 2010
Nature Reviews Microbiology

Volume: 9, P: 15-26
AID and mismatch repair in antibody diversification

Alberto Martin
Matthew D. Scharff
Reviews01 Aug 2002
Nature Reviews Immunology

Volume: 2, P: 605-614
Mismatch repair goes meiotic

Terry J. Hassold
News & Views01 Jul 1996
Nature Genetics

Volume: 13, P: 261-262
The impact of home based ventilator dependence on family life

C A Glass
Research01 Feb 1993
Spinal Cord

Volume: 31, P: 93-101
Millimetre observations of quasar Q0420–388

W. A. Sherwood
G. V. Schultz
E. Kreysa
Research28 May 1981
Nature

Volume: 291, P: 301-303
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

Claire M. Fraser
Sherwood Casjens
J. Craig Venter
Research01 Dec 1997
Nature

Volume: 390, P: 580-586
The crystal structure of DNA mismatch repair protein MutS binding to a G·T mismatch

Meindert H. Lamers
Anastassis Perrakis
Titia K. Sixma
Research12 Oct 2000
Nature

Volume: 407, P: 711-717
(CAG)_n-hairpin DNA binds to Msh2–Msh3 and changes properties of mismatch recognition

Barbara A L Owen
Zungyoon Yang
Cynthia T McMurray
Research17 Jul 2005
Nature Structural & Molecular Biology

Volume: 12, P: 663-670
The genome sequence of Rickettsia prowazekii and the origin of mitochondria

Siv G. E. Andersson
Alireza Zomorodipour
Charles G. Kurland
Research12 Nov 1998
Nature

Volume: 396, P: 133-140

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