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Strong correlations between electrons in topological surface states drive the formation of surface van Hove singularities. These may be linked to charge density waves in the surface states.

Patients with Parkinson’s disease treated with fetal tissue are assessed 3 years after surgery.

In a first-in-human phase 1/2 study in seven patients with sickle cell disease, autologous hematopoietic stem cell lentiviral gene therapy using reduced-intensity conditioning was considered feasible and safe, achieving >80% reduction in the frequency of vaso-occlusive events.

The Li dendrites and adverse Li-electrolyte reactions hinder the practical use of Li metal batteries. Here, authors propose an organic/inorganic artificial solid electrolyte interphase, where an outer metal layer ensures uniform Li nucleation and a F-rich inner layer acts as an electronic insulator.

Subsoils are vital for ecosystem sustainability due to their nutrient stocks and microbial diversity. This study across 40 agricultural sites in China found that, compared with topsoils, subsoils are more sensitive and variable under disturbance, highlighting the need to manage both layers in sustainability efforts.

Despite the therapeutic interest in targeting CDK2, developing a selective CDK2 inhibitor has been challenging. Here, the authors describe a potent and selective CDK2 inhibitor that binds an allosteric pocket, preventing activating protein partners from binding and showing potential as a contraceptive.

Water resource development can have important downstream impacts on ecological functioning and affect socio-economic outcomes associated with marine fisheries. This study modelled the catchment-to-coast effects of reductions in freshwater flowing to estuaries in Australia.

Population growth and associated increases in food and feed demand may drive cropland expansion at the expense of natural area and biodiversity, as well as higher greenhouse gas emissions. This study shows how a more efficient and better targeted use of phosphorus is key to avoiding such environmental problems.

Can human-aware artificial intelligence help accelerate science? In this article, the authors incorporate the distribution of human expertise by training unsupervised models on simulated inferences cognitively accessible to experts and show that this substantially improves the models’ predictions of future discoveries, but also enables AI to generate high-value alternatives that complement human discoveries.

Animal propulsors—wings and fins—typically bend during motion. Here, the authors analysed video data on animal propulsor bending and find that, for propulsion within inertially dominated flows, the flexion angles and the positions of the point of flexion are similar across the animal kingdom.

It’s unclear how fragmented habitats affect species coexistence in bacterial communities. Here, using microfluidic chip experiments and simulations, the authors find that fragmentation leads to more diverse ecological outcomes mostly due to underlying phenotypic variation in founder cells and their stochastic assembly.

DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syndrome causing disease mutations.

Solar cells based on CdTe are a promising low-cost alternative to mainstream Si devices, but they usually produce voltages below 900 mV. Burst et al. now show that open-circuit voltages greater than 1 V can be achieved by doping the CdTe with a group V element.

C9orf72 ALS/FTD polyGR and polyPR knock-in mice show cortical hyperexcitability and motor neuron loss accompanied by an increase in extracellular matrix proteins in the spinal cord that is conserved in patient iPS cell-derived neurons and is neuroprotective.

Redox mediators catalyse the otherwise slow and energy-inefficient cycling of Li–S and Li–O₂ batteries. An investigation of the kinetics of mediated Li₂S and Li₂O₂ oxidations when the redox potentials of various mediators are tuned reveals threshold potentials for high reaction rates, which can be optimized in multiple ways.

Accounting for experimental data on hydrous peridotites reduces the estimated water recycled into the deep mantle during subduction and suggests sea-level stability over geological time, according to subduction zone thermopetrological modelling.

Manipulation of surface energy and wetting properties of solids may impact a variety of processes, including membrane fouling. Here the authors tune properties of vermiculite laminates from superhydrophilic to hydrophobic by cation exchange, and demonstrate potential for fouling resistant oil–water separation.

Bollen et al. tracked changes in the emotions of Twitter users before and after they expressed a feeling online. Emotions grow quickly before—and decrease rapidly after—their expression, confirming previous affect labeling studies showing that putting one’s feelings into words can alleviate their intensity.

Combination therapies simultaneously inhibiting different therapeutic targets in cancer is challenged by individual pharmacokinetic profiles. Here, the authors generate an orally provided multi-targeted kinase inhibitor that is lymphatic absorbed and increases survival in a murine model of myelofibrosis.

Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.

A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher educational attainment in slowing disease progression.

Understanding strain dynamics and their relationship with crystallographic facets have been largely unexplored. Here the authors demonstrate how the 3D lattice displacement and strain evolution depend on the crystallographic facets of Pt nanoparticles during CO oxidation reaction, providing new insights in the relationship between facet-related surface strain and chemistry.

Joel Hirschhorn and colleagues report results of a large-scale genome-wide association and replication study for obesity-related traits. The newly discovered loci are enriched for genes expressed in the central nervous system, and may thus contribute to weight gain by modulating food intake. Similar results are reported in a related study by Gudmar Thorleifsson and colleagues.

The Sun’s light stable isotopes compositions can help us understand how our solar system formed. Here, the authors find that solar C is depleted relative to bulk Earth indicating that the ¹³C enrichment of the terrestrial planets is from CO self-shielding or inheritance from the parent cloud.