Nature Search

HippoMaps: multiscale cartography of human hippocampal organization

HippoMaps provides an open-source resource for studying the human hippocampus at different scales and with different modalities such as histology, fMRI, structural MRI and EEG.

Jordan DeKraker
Donna Gift Cabalo
Boris C. Bernhardt
ResearchOpen Access01 Oct 2025
Nature Methods

P: 1-12
Theta oscillations and minor hallucinations in Parkinson’s disease reveal decrease in frontal lobe functions and later cognitive decline

In this longitudinal study, Bernasconi and colleagues explore the association of minor hallucinations and theta oscillations with the future occurrence of cognitive decline in patients with early Parkinson’s disease.

Fosco Bernasconi
Javier Pagonabarraga
Olaf Blanke
Research29 Jun 2023
Nature Mental Health

Volume: 1, P: 477-488
Advances in MRI for 'cryptogenic' epilepsies

Drug-resistant focal epilepsy is potentially curable by surgery, but conventional MRI based on visual evaluation is sometimes unable to reveal a lesion for resection. In this Review, Bernasconi and colleagues consider recent advances in brain imaging for the detection of lesions in cases of so-called cryptogenic epilepsy, covering developments in MRI morphometry, computational modeling and diffusion tensor imaging.

Andrea Bernasconi
Neda Bernasconi
Dewi Schrader
Reviews18 Jan 2011
Nature Reviews Neurology

Volume: 7, P: 99-108
Excessive Thyrotropin Response to Thyrotropin-releasing Hormone in Pseudohypoparathyroidism

Edmond A Werder
Ruth Illig
Andreas Fanconi
Research01 Jan 1975
Pediatric Research

Volume: 9, P: 12-16
Changes in Dopaminergic Control of Circulating Melanocyte-Stimulating Hormone-Related Peptides at Puberty

Fabio Facchinetti
Sergio Bernasconi
Andrea R Genazzani
Research01 Jul 1995
Pediatric Research

Volume: 38, P: 91-94
Plasma Adrenocorticotropin, Cortisol, and Dehydroepiandrosterone Response to Corticotropin-Releasing Factor in Normal Children during Pubertal Development

Andrea Attanasio
Ralf Rokamp
Derek Gupta
Research01 Jul 1987
Pediatric Research

Volume: 22, P: 41-44
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Histopathology-based protein multiplex generation using deep learning

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Sonali Andani
Boqi Chen
Gunnar Rätsch
ResearchOpen Access04 Aug 2025
Nature Machine Intelligence

Volume: 7, P: 1292-1307
Imaging the epileptic brain—time for new standards

Therapeutic management of patients with epilepsy is often challenging, particularly in those who are pharmacoresistant. In these patients, the only option to control seizures is elective surgery. Optimization of MRI acquisition sequences might mean early identification of patients, thereby speeding up surgical intervention.

Neda Bernasconi
Andrea Bernasconi
News & Views14 Jan 2014
Nature Reviews Neurology

Volume: 10, P: 133-134
Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Nicola Miglino
Nora C. Toussaint
Andreas Wicki
Amendments and CorrectionsOpen Access01 Aug 2025
Nature Medicine

Volume: 31, P: 2817-2818
Feasibility of multiomics tumor profiling for guiding treatment of melanoma

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

Nicola Miglino
Nora C. Toussaint
Andreas Wicki
ResearchOpen Access27 May 2025
Nature Medicine

Volume: 31, P: 2430-2441
Correction: Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease

Chi A Ma
Jeffrey R Stinson
Joshua D Milner
Amendments and Corrections27 Oct 2017
Nature Genetics

Volume: 49, P: 1661
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

Epilepsy is a brain network disorder with associated genetic risk factors. Here, the authors show that spatial patterns of transcriptomic vulnerability co-vary with structural brain network alterations in focal and generalized epilepsy.

Sara Larivière
Jessica Royer
Boris C. Bernhardt
ResearchOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

Rebekka Wegmann
Ximena Bonilla
Alexandre P. A. Theocharides
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Molecular technology and the recombinant TSH have changed diagnostics of thyroid carcinoma with positive I-131 whole body scan but low serum thyroglobulin

Liliana Montella
Michele Caraglia
Marco Salvatore
ResearchOpen Access01 Jun 2004
Experimental & Molecular Medicine

Volume: 36, P: 268-273
Colonization of the human gut by bovine bacteria present in Parmesan cheese

Some microorganisms may be transferred across the food production chain and, potentially, colonize the human gut. Here, Milani et al. provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese.

Christian Milani
Sabrina Duranti
Francesca Turroni
ResearchOpen Access20 Mar 2019
Nature Communications

Volume: 10, P: 1-12
Germline hypomorphic CARD11 mutations in severe atopic disease

Erwin Gelfand, Andrew Snow, Joshua Milner and colleagues identify heterozygous CARD11 mutations associated with severe atopic disease in eight individuals from four families. They further show that the mutant CARD11 proteins exhibit both loss-of-function and dominant-interfering activity and that the cellular defects in patient T cells can be partially rescued by supplementing with glutamine.

Chi A Ma
Jeffrey R Stinson
Joshua D Milner
Research19 Jun 2017
Nature Genetics

Volume: 49, P: 1192-1201
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Robbiani and colleagues show that antibodies against specific chemokines are detected in COVID-19 convalescents and may modulate the inflammatory response and disease outcome.

Jonathan Muri
Valentina Cecchinato
Davide F. Robbiani
ResearchOpen Access06 Mar 2023
Nature Immunology

Volume: 24, P: 604-611
Exploring the under-investigated “microbial dark matter” of drinking water treatment plants

Antonia Bruno
Anna Sandionigi
Maurizio Casiraghi
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer

Long-read single-cell RNA sequencing is capable of detecting isoform-level gene expression and genomic alterations such as mutations and gene fusions, thereby providing cell-specific genotype-phenotype information. Here, the authors use long-read scRNA-seq on metastatic ovarian cancer samples and detect cell-type specific isoforms and gene fusions that may otherwise be misclassified in short-read data.

Arthur Dondi
Ulrike Lischetti
Niko Beerenwinkel
ResearchOpen Access27 Nov 2023
Nature Communications

Volume: 14, P: 1-19
Multi-contrast submillimetric 3 Tesla hippocampal subfield segmentation protocol and dataset

Jessie Kulaga-Yoskovitz
Boris C. Bernhardt
Neda Bernasconi
ResearchOpen Access10 Nov 2015
Scientific Data

Volume: 2, P: 1-9
Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Gianluca Cavallaro
Anna Grassi
Alessandro Rambaldi
ResearchOpen Access21 Aug 2024
Blood Cancer Journal

Volume: 14, P: 1-7
Individual reproductive success in Norway spruce natural populations depends on growth rate, age and sensitivity to temperature

Camilla Avanzi
Katrin Heer
Andrea Piotti
Research16 Mar 2020
Heredity

Volume: 124, P: 685-698
Macroscale and microcircuit dissociation of focal and generalized human epilepsies

Weng et al. harness multimodal neuroimaging and computational modeling to examine whole-brain dysfunction in patients with generalized (GE) and temporal lobe epilepsy (TLE) as well as healthy controls. They find more severe microcircuit and macroscale imbalances in TLE than GE, illustrating the power of this integrated approach.

Yifei Weng
Sara Larivière
Boris C. Bernhardt
ResearchOpen Access18 May 2020
Communications Biology

Volume: 3, P: 1-11
Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Manon Vouga
Guillaume Favre
Alice Panchaud
ResearchOpen Access06 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Changes of Serum Allopregnanolone Levels in the First 2 Years of Life and during Pubertal Development

Michela Fadalti
Felice Petraglia
Sergio Bernasconi
Research01 Sept 1999
Pediatric Research

Volume: 46, P: 323-327
An Open MRI Dataset For Multiscale Neuroscience

Jessica Royer
Raúl Rodríguez-Cruces
Boris C. Bernhardt
ResearchOpen Access15 Sept 2022
Scientific Data

Volume: 9, P: 1-12
Fracture dolomite as an archive of continental palaeo-environmental conditions

Palaeo-environmental conditions can be recorded in low-temperature continental archives, according to geochemical and isotopic analyses of dolomitic fracture infills at Erzberg, Austria

Andre Baldermann
Florian Mittermayr
Ronny Boch
ResearchOpen Access21 Oct 2020
Communications Earth & Environment

Volume: 1, P: 1-12
Alazami syndrome: the first case of papillary thyroid carcinoma

Ivan Ivanovski
Stefano Giuseppe Caraffi
Livia Garavelli
Research28 Oct 2019
Journal of Human Genetics

Volume: 65, P: 133-141
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology

The authors present a robust diagnostic algorithm based on digital pathology and image analysis that quantifies intratumoral and stromal CD8+ T-cell densities in the tumor center and invasive margin compartment in metastatic melanoma. Spatial CD8+ T-cell densities are translated into the clinically relevant immune diagnostic categories “inflamed”, “excluded”, and “desert”. Their approach also allows efficient immune phenotyping of metastatic lesions, on biopsy material or even in the absence of material from the invasive margin.

Bettina Sobottka
Marta Nowak
Viktor Hendrik Koelzer
ResearchOpen Access26 Aug 2021
Laboratory Investigation

Volume: 101, P: 1561-1570

Search

HippoMaps: multiscale cartography of human hippocampal organization

Theta oscillations and minor hallucinations in Parkinson’s disease reveal decrease in frontal lobe functions and later cognitive decline

Advances in MRI for 'cryptogenic' epilepsies

Excessive Thyrotropin Response to Thyrotropin-releasing Hormone in Pseudohypoparathyroidism

Changes in Dopaminergic Control of Circulating Melanocyte-Stimulating Hormone-Related Peptides at Puberty

Plasma Adrenocorticotropin, Cortisol, and Dehydroepiandrosterone Response to Corticotropin-Releasing Factor in Normal Children during Pubertal Development

Mapping the human genetic architecture of COVID-19

Histopathology-based protein multiplex generation using deep learning

Imaging the epileptic brain—time for new standards

Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Correction: Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

Molecular technology and the recombinant TSH have changed diagnostics of thyroid carcinoma with positive I-131 whole body scan but low serum thyroglobulin

Colonization of the human gut by bovine bacteria present in Parmesan cheese

Germline hypomorphic CARD11 mutations in severe atopic disease

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Exploring the under-investigated “microbial dark matter” of drinking water treatment plants

Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer

Multi-contrast submillimetric 3 Tesla hippocampal subfield segmentation protocol and dataset

Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Individual reproductive success in Norway spruce natural populations depends on growth rate, age and sensitivity to temperature

Macroscale and microcircuit dissociation of focal and generalized human epilepsies

Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Changes of Serum Allopregnanolone Levels in the First 2 Years of Life and during Pubertal Development

An Open MRI Dataset For Multiscale Neuroscience

Fracture dolomite as an archive of continental palaeo-environmental conditions

Alazami syndrome: the first case of papillary thyroid carcinoma

Establishing standardized immune phenotyping of metastatic melanoma by digital pathology

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