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Scanning tunnelling microscopy is used to image pristine electrostatically defined quantum Hall edge states in graphene with high spatial resolution and demonstrate their interaction-driven restructuring.

Rhombohedral tetralayer graphene aligned to a hexagonal boron nitride substrate hosts gate-tunable superconductivity and quantized anomalous Hall states, and thermodynamic compressibility measurements further show a fractional Chern insulator at zero magnetic field, paving the way for new hybrid interfaces between superconductors and topological edge states.

The superconducting proximity effect has not been experimentally demonstrated in a quantum anomalous Hall insulator. Now this effect is observed in the chiral edge state of a ferromagnetic topological insulator.

Controlling emission and propagation of acoustic waves offers new design opportunities for acoustic devices. Here the authors demonstrate such controls thanks to the emergence of a synthetic pseudo-spin in two-dimensional acoustic metamaterial.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Switching of magnetic behaviour is one of the main ideas that drives spintronics. Now, magnetic switching via spin-orbit torque is shown in a moiré bilayer, introducing a platform for spintronic applications.

Applying magnetic and electric fields to twisted bilayer graphene creates an electron–hole bilayer that features helical 1D edge modes and fractional quantum Hall states.

Quantum Hall states are observed in monolayer graphene at even-denominator fractional filling of the lowest Landau level. This is linked to transitions in the spin and valley structure of the ground state.

Inducing phase transitions in atomically thin films of layered materials requires efficient electrostatic doping techniques to reach high carrier densities. Here, the authors present a doping technique which induces superconductivity by reaching high n-doping density in few-layered MoS₂on glass substrates.

The extra states sometimes observed in graphene’s quantum Hall characteristics have been presumed to be the result of broken SU(4) symmetry. Magnetotransport measurements of high-quality graphene in a tilted magnetic field finally prove this is indeed the case.

A transient topological response in graphene is driven by a short pulse of light. When the Fermi energy is in the predicted band gap the Hall conductance is around two conductance quanta. An ultrafast detection technique enables the measurement.

Zihuan Liu and colleagues reported measurements on a MEMS resonator that reaches a mechanical velocity of 50 m/s, a ten-fold improvement over typical devices. These results show that operating MEMS near limits could enable much more sensitive inertial sensors for navigation.

We report both spin- and orbital-sourced Berry curvature in LaAlO₃/SrTiO₃ interfaces grown along the [111] direction.

Precise control of electrons in two-dimensional materials has been limited by fabrication techniques for local gates that introduce disorder. Now, a technique allows patterning of sub-100 nm features and fabrication of very clean interfaces.

The authors use spin waves to demonstrate that charged quantum Hall skyrmions exist away from integer filling. They also see evidence of several fractional skyrmion states.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Helicity of photons is exploited for preferential emission direction and sorting of valley-polarized excitons is achieved at room temperature.

Smooth topological photonic interfaces lead to less localized boundary modes which improves their guiding characteristics in both spin- and valley Hall metasurfaces. The modes become insensitive to the lattice details, showcasing improved bandgap crossing and longer propagation distances.

Fractional Chern insulators, and their time-reversal analogs, fractional topological insulators, are realizations of topological order in flat-band electronic systems; while the former have been realized experimentally in twisted bilayer MoTe₂, the latter have remained more elusive. Here, using exact diagonalization calculations, the authors propose routes towards engineering fractional topological insulators in twisted bilayer MoTe₂ and other moiré materials.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The Haldane model is a paradigmatic example of topological behaviour but has not previously been implemented in condensed-matter experiments. Now a moiré bilayer is shown to realize this model with the accompanying quantized transport response.

A nanoscale superconducting sensor used to map the magnetic fringe fields in twisted bilayers of MoTe₂ shows the formation of fractional Chern insulator states at zero magnetic field.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Various fractional quantum Hall phases are observed in a new generation of bilayer-graphene-based van der Waals heterostructures, including an even-denominator state predicted to harbour non-Abelian anyons.

Over the last 15 years, the content of Nature Physics has covered an enormous breadth of subjects at the forefront of physics. The journal’s past and present editors recount their favourite papers and what made chaperoning them to publication special.

This study associates p53 loss and brain metastasis in breast cancer. Mechanistically, p53-null tumors recruit astrocytes that provide substrates for enhanced fatty acid synthesis via upregulated SCD1 expression, representing a targetable axis in the disease.

A study shows that rhombohedral graphene is an ideal platform for well-controlled tests of many-body theory and reveals that magnetism in moiré materials is fundamentally itinerant in nature.

Graphene systems exhibit flavor order transitions driven by tuning parameters. Here, the authors demonstrate an optical technique for detecting flavor textures in graphene via the exciton response of a proximal transition metal dichalcogenide layer.

Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Topological order for sound remains largely unexplored. Here, Khanikaevet al. introduce the concept of topological order in classical acoustics, realizing robust topological protection and one-way edge propagation of sound in a suitably designed resonator lattice, thus expanding the ability to tailor acoustic waves.

An electronic analogue of the Pomeranchuk effect is present in twisted bilayer graphene, shown by the stability of entropy in a ferromagnetic phase compared to an unpolarized Fermi liquid phase at certain high temperatures.

A lift-off and transfer method enables the fabrication of efficient three-dimensional racetrack memory devices fabricated from freestanding magnetic heterostructures on a prepatterned substrate and may—in the future—allow for advanced three-dimensional nanostructures in next-generation nanoelectronic devices with a low device footprint.

Non-volatile electrical switching of magnetic order in an orbital Chern insulator is experimentally demonstrated using a moiré heterostructure and analysis shows that the effect is driven by topological edge states.

Itinerant magnetism in rhombohedral multilayer graphene shows a large excess entropy from magnetic fluctuations above its critical temperature—typically only associated with local moments—which implies the decoupling of charge and isospin degrees of freedom, and results in the isospin Pomeranchuk effect.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in mTOR–membrane engagement and full enzyme activation.

Analysis of human Robertsonian chromosomes originating from 13, 14 and 21 reveal that they result from breaks at the SST1 macrosatellite DNA array and recombination between homologous sequences surrounding SST1.

In this work light and matter have been coupled in a strong interaction between exciton resonances and topological photonic bands. The authors herein demonstrate a Z2 spin-Hall topological polaritonic phase enabling new coupling schemes in valleytronics and spintronics.

Forest restoration in LMICs can contribute to global C mitigation targets. Here, the authors assess the economic feasibility of forest restoration methods in Panama, i.e. natural regeneration, native species plantings, and enrichment planting, showing that not all methods are economically viable.