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Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

With over 2,000 newly identified data points, this study estimates 2,525 million m³ of wood fuel removals globally in 2019, approximately 30% higher than previously understood. Global production of wood charcoal is estimated at 70.5 million tonnes, approximately 50% higher than previous values.

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Io’s distribution of volcanoes shows an eastward shift not explained by existing tidal heating models. Here, the authors show that feedback between tidal heating and interior properties naturally forms a heating pattern with a longitudinal shift.

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

Here the authors isolate monoclonal antibodies specific for Plasmodium vivax apical membrane antigen 1, and characterize the epitope of one antibody that inhibits invasion of reticulocytes and hepatocytes, and reduces liver infection in a mouse model.

High pathogenicity avian influenza virus has a wide host range and has been detected across a large geographic area. Here, the authors present evidence of spread to the Antarctic and sub-Antarctic regions, with signs of clinical infection and positive virus detection in birds and elephant seals.

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

DNA variant calling methods based on deep neural networks can use local haplotyping information with long-reads to improve genotyping accuracy, however this increases computational complexity. Here the authors develop an approximate haplotagging method that simplifies the process and enables state-of-the-art variant calling performance with multiple sequencing platforms.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Mapping of the global potential of atmospheric water harvesting using solar energy shows that it could provide safely managed drinking water for a billion people worldwide based on climate suitability.

All-solid-state batteries with silicon anodes have high capacities but low initial coulombic efficiencies (ICEs) because of first cycle irreversible capacity loss. Here, the authors report a prelithiation strategy to improve ICEs and reversibility.

The Fermi-Hubbard model represents one of the benchmarks for testing quantum computational methods for condensed matter. Here, the authors are able to reproduce qualitative properties of the model on 1 × 8 and 2 × 4 lattices, by running a VQE-based algorithm on a superconducting quantum processor.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

This study shows that a multitrophic community model jointly recapitulates diel rhythms in abundances of Prochlorococcus picocyanobacteria, as well as viral infection, viral abundances and grazer abundances. Model-data integration implies that grazing predominantly controls Prochlorococcus abundances in surface waters of the North Pacific Subtropical Gyre, despite high viral densities.

As quantum information technologies develop into practical computational engines, many technical issues must be considered. Devittet al.estimate the resources needed to perform prime factorization with Shor’s algorithm on an atom-optics quantum computer and show how to optimize the computer's performance.

Studying changes in the metabolic properties of kidney cancer in patients reveals an increased need for mitochondrial metabolism as tumors metastasize from the kidney to distant organs.

Which combination of current genome sequencing and assembly approaches results in high-quality, complete diploid genome assemblies is determined.

Juno’s global infrared mapping of Jupiter’s moon Io determined the distribution as well as the energy output of its volcanoes. Spatial differences emerge, with the equator more active than the polar zones and more heat flow at the north pole than at the south, indicative of an uneven lithosphere.

MILTON uses phenotype information in the UK Biobank to identify clinical biomarkers and other quantitative traits that characterize diseases. It then constructs augmented cohorts by predicting undiagnosed individuals, improving power to discover gene–disease relationships.

The role of dorsal hippocampus in driving reinforcement remains to be determined. Here, authors show that dorsal hippocampus-driven reinforcing behaviors are mediated via inputs to dynorphin neurons in the dorsal medial nucleus accumbens.

MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression of p53 target genes.

A multi-omic analysis of pancreatic cancer identifies spatially resolved, heterogeneous cell populations including transitional cell types. Analysis of primary samples identifies treatment-related changes in cross-talk between tumor and stromal cells.

A multi-omics approach reveals that bifidobacteria metabolize the prebiotic lactulose to produce acetate and deconjugate bile acids, which is associated with reduced densities of drug-resistant pathogens and decreased incidences of infection in patients with liver disease.

Graphene doesn’t usually have a bandgap but one can appear when the two-dimensional material is placed on a hexagonal boron nitride substrate. Jung et al. now develop a theory that indicates that this occurs because the graphene’s carbon atoms structurally relax when placed on boron nitride.

COVID-19 vaccines have been associated with rare cardiovascular and thrombotic complications. Here, the authors use population-based longitudinal electronic health record data from ~46 million adults in England to quantify these outcomes following different vaccine doses and schedules.

Human-generated noise and night lighting affect breeding habits and fitness in birds, implying that sensory pollutants must be considered alongside other environmental factors in assessing biodiversity conservation.

Wang et al. developed a bisulfite-free method termed DM-Seq that leverages an unnatural enzyme–substrate pair coupled with a DNA deaminase to sequence 5-methylcytosine at base resolution in sparse DNA samples, circumventing the limitations of chemical deamination methods.

Raman and fluorescence spectra, consistent with several species of aromatic organic molecules, are reported in the Crater Floor sequences of Jezero crater, Mars, suggesting multiple mechanisms of organic synthesis, transport, or preservation.

The giant planet 8 Ursae Minoris b seems to have avoided engulfment by its giant host star through a stellar merger that either affected the evolution of the host star or produced 8 Ursae Minoris b as a second-generation planet.

MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound targets sharing MYC associated pathways.

In this Consensus Statement, the authors outline strategies for processing, analysing and interpreting low-biomass microbiome samples, and provide recommendations to minimize contaminants.

Competition is fierce in the microbial world, making evolutionary training and fitness essential for a microorganism to survive and thrive. To honour this spirit, in this Essay an expert panel has selected seven special events to make up the inaugural Microbial Olympics.

Although materials used in electrochemical devices for energy applications would benefit from the precise structural control that can be achieved by using silica sol–gel chemistry, such synthetic approaches typically result in insulating porous materials. Now, a simple approach based on a multifunctional sol–gel precursor allows the synthesis of porous nanocomposites with metallic percolation networks exhibiting high electrical conductivity.

The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both biochemically and in cells.

Reverse haemolytic plaque assays make possible the microscopic visualization of hormone release at the single-cell level. The method can quantify functional differences among hormone secretors of a given type.

Despite the burgeoning field of uranium-ligand multiple bond chemistry, analogous thorium compounds remain scarce. Here, the authors synthesize and characterize a series of thorium complexes with multiple bonds to phosphorus, and probe their 5f versus 6d orbital bonding character.

Milk proteins from the North Caucasus and Eurasian steppe support the initial development of sheep dairying during the Eneolithic, followed by subsequent intensification and husbandry of different dairy animals during the Middle Bronze Age and later periods.

TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational changes in TrkA to the opening of the TrkH channel and further support the proposed gating mechanism with functional studies.