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Showing 1–50 of 69 results

Advanced filters: Author: Atsushi Oshima Clear advanced filters

A Near Complete Genome Assembly of the Oshima Cherry Cerasus speciosa

Kazumichi Fujiwara
Atsushi Toyoda
Tsuyoshi Koide
ResearchOpen Access04 Feb 2025
Scientific Data

Volume: 12, P: 1-16
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Enigmatic tubular ultrastructure in the bacterial defensive symbiont of the Asian citrus psyllid Diaphorina citri

Chihong Song
Junnosuke Maruyama
Atsushi Nakabachi
ResearchOpen Access18 Sept 2025
npj Imaging

Volume: 3, P: 1-11
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization

DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, but their therapeutic effects are not satisfactory. Here, the authors show that inhibition of TOPORS, which encodes a ubiquitin E3 ligase, augments the efficacy of HMAs through DNMT1 stabilization.

Satoshi Kaito
Kazumasa Aoyama
Atsushi Iwama
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model

Werner syndrome (WS) is a rare inherited disorder characterized by premature aging and atherosclerosis. Here, the authors mimic atherosclerosis with iPSC-derived macrophages and vascular cells and find that type I IFN signaling triggered by the reactivation of retrotransposable elements in WS macrophages induces vascular dysfunction.

Sudip Kumar Paul
Motohiko Oshima
Naoya Takayama
ResearchOpen Access10 Jun 2024
Nature Communications

Volume: 15, P: 1-17
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Renin-Angiotensin System in the Brain as a New Target of Antihypertensive Therapy

Satoru Ito
Kazutoshi Komatsu
Atsushi Hirayama
Editorial01 Aug 2008
Hypertension Research

Volume: 31, P: 1487-1488
Genetic isolation of an amphidromous goby species, Luciogobius ryukyuensis, highlights limited gene flow in small island populations

Ken Maeda
Hirozumi Kobayashi
Vincent Laudet
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Haematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here the authors demonstrate that differentially accessible regions in aged HSC chromatin are enriched for stress-responsive enhancers and act as an epigenetic hub to augment transcriptional responses of aged HSCs to external stimuli.

Naoki Itokawa
Motohiko Oshima
Atsushi Iwama
ResearchOpen Access16 May 2022
Nature Communications

Volume: 13, P: 1-15
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis

Fibroblast growth factor (FGF)18 plays pleiotropic roles, including bone development and carcinogenesis, however, its precise role in liver fibrosis remains incompletely understood. Here, the authors show that FGF18 promotes liver fibrosis by stimulating hepatic stellate cell proliferation, without concomitant upregulation of profibrotic genes.

Yuichi Tsuchiya
Takao Seki
Hiroyasu Nakano
ResearchOpen Access09 Oct 2023
Nature Communications

Volume: 14, P: 1-20
Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans

Atsushi Higashitani
Toko Hashizume
Akira Higashibata
ResearchOpen Access01 Sept 2021
npj Microgravity

Volume: 7, P: 1-8
Neurological improvement is associated with neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament

Masao Koda
Toshitaka Yoshii
Masashi Yamazaki
ResearchOpen Access07 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population

Michiaki Kubo and colleagues report a genome-wide association study for age-related macular degeneration in individuals of Japanese ancestry. They identify two genetic loci newly associated with this disease.

Satoshi Arakawa
Atsushi Takahashi
Michiaki Kubo
Research11 Sept 2011
Nature Genetics

Volume: 43, P: 1001-1004
Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia

Leyla Akman
Atsushi Yamashita
Serap Aksoy
Research03 Sept 2002
Nature Genetics

Volume: 32, P: 402-407
High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon

Mami Matsuda
Atsushi Yamanaka
Ryosuke Suzuki
ResearchOpen Access09 Nov 2018
Scientific Reports

Volume: 8, P: 1-8
Obesity accelerates hair thinning by stem cell-centric converging mechanisms

Obesity in mice, caused by a high-fat diet, induces hair loss as a result of changes in the differentiation of hair follicle stem cells.

Hironobu Morinaga
Yasuaki Mohri
Emi K. Nishimura
Research23 Jun 2021
Nature

Volume: 595, P: 266-271
Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 expression, promoting the development of this cancer.

Sho Kubota
Kenji Tokunaga
Goro Sashida
ResearchOpen Access10 Apr 2019
Nature Communications

Volume: 10, P: 1-16
Trapped radical behavior of electron beam irradiated polytetrafluoroethylene fine powder at various temperatures

Akihiro Oshima
Hiroto Horiuchi
Masakazu Washio
ResearchOpen Access25 May 2021
Scientific Reports

Volume: 11, P: 1-7
Silicon twisted cone structure produced by optical vortex pulse with structure evaluation by radiation hydrodynamic simulation

Daisuke Nakamura
Ryohei Tasaki
Takeshi Higashiguchi
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-11
Empagliflozin attenuates acute kidney injury after myocardial infarction in diabetic rats

Atsushi Kuno
Yukishige Kimura
Tetsuji Miura
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-9
Pt-free carbon-based fuel cell catalyst prepared from spherical polyimide for enhanced oxygen diffusion

Yuta Nabae
Shinsuke Nagata
Tsutomu Aoki
ResearchOpen Access18 Mar 2016
Scientific Reports

Volume: 6, P: 1-7
Shoulder Stretching Intervention Reduces the Incidence of Shoulder and Elbow Injuries in High School Baseball Players: a Time-to-Event Analysis

Hitoshi Shitara
Atsushi Yamamoto
Kenji Takagishi
ResearchOpen Access27 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament

Hiroaki Nakashima
Shiro Imagama
Atsushi Okawa
ResearchOpen Access14 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

Mutations in the EZH2 gene are found in myelodysplastic syndrome (MDS) and are often accompanied by mutations in RUNX1. Here, the authors develop a mouse model of MDS and show that EZH2loss enhances the RUNX1-mediated MDS pathology.

Goro Sashida
Hironori Harada
Atsushi Iwama
Research23 Jun 2014
Nature Communications

Volume: 5, P: 1-14
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis

Toshihiko Ishimitsu
Tomoko Kameda
Hiroaki Matsuoka
Research01 Jul 2007
Hypertension Research

Volume: 30, P: 621-626
Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Sho Kubota
Kenji Tokunaga
Goro Sashida
Amendments and CorrectionsOpen Access28 Aug 2019
Nature Communications

Volume: 10, P: 1
Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils

Pulmonary hypertension is characterized by increased pulmonary arterial pressure, driven in part by inflammatory infiltrates. Here, the authors show that in mice, transgenic expression of mutant JAK2 leads to clonal hematopoiesis and lung accumulation of elastase- and cytokine-expressing neutrophils, and that the phenotype can be reversed by ALK1 inhibition.

Yusuke Kimishima
Tomofumi Misaka
Yasuchika Takeishi
ResearchOpen Access26 Oct 2021
Nature Communications

Volume: 12, P: 1-18
Anthropogenic iron oxide aerosols enhance atmospheric heating

Iron oxide nanoparticles contribute to shortwave absorption in the form of desert dust. Motekiet al. show that iron oxide particles of anthropogenic origin, potentially from motor vehicles and blast furnaces, also contribute to atmospheric heating over East Asia.

Nobuhiro Moteki
Kouji Adachi
Yutaka Kondo
ResearchOpen Access16 May 2017
Nature Communications

Volume: 8, P: 1-11
Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model

Mitsuaki Ono
Masamitsu Oshima
Takuo Kuboki
ResearchOpen Access16 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

Ryuji Oshima
Takafumi Hasegawa
Nobuyuki Tanaka
ResearchOpen Access26 Apr 2016
Scientific Reports

Volume: 6, P: 1-15
Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus

Atsushi Okabe
Sayaka Funata
Atsushi Kaneda
ResearchOpen Access11 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Oxidation-induced nanolite crystallization triggered the 2021 eruption of Fukutoku-Oka-no-Ba, Japan

Kenta Yoshida
Akira Miyake
Shigeaki Ono
ResearchOpen Access09 May 2023
Scientific Reports

Volume: 13, P: 1-9
A comprehensive risk factor analysis using association rules in people with diabetic kidney disease

Tadashi Toyama
Miho Shimizu
Yasunori Iwata
ResearchOpen Access20 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
Coastal ecological impacts from pumice rafts

Yoshikazu Ohno
Akira Iguchi
Atsushi Suzuki
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Impact of obesity on cervical ossification of the posterior longitudinal ligament: a nationwide prospective study

Kanji Mori
Toshitaka Yoshii
Atsushi Okawa
ResearchOpen Access25 May 2022
Scientific Reports

Volume: 12, P: 1-10
Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease

Syunichiro Kimura
Kenichi Tanaka
Hirokazu Takahashi
ResearchOpen Access02 Aug 2021
Scientific Reports

Volume: 11, P: 1-9
BAG-1 accelerates cell motility of human gastric cancer cells

Yasuyoshi Naishiro
Masaaki Adachi
Kohzoh Imai
Research25 May 1999
Oncogene

Volume: 18, P: 3244-3251
The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

Yurie Nagai
Naoya Mimura
Emiko Sakaida
ResearchOpen Access22 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis

Daisuke Shinoda
Yaeko Nakajima-Takagi
Atsushi Iwama
Research08 Sept 2021
Leukemia

Volume: 36, P: 452-463
EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma

Yuko Kusakabe
Tetsuhiro Chiba
Naoya Kato
ResearchOpen Access01 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Genetic and transcriptional landscape of plasma cells in POEMS syndrome

Yuhei Nagao
Naoya Mimura
Chiaki Nakaseko
Research11 Jan 2019
Leukemia

Volume: 33, P: 1723-1735
Intraoperative electrophysiological evaluations of macular function during peripheral scleral indentation

Goichi Akiyama
Celso Soiti Matsumoto
Yozo Miyake
ResearchOpen Access20 Oct 2016
Scientific Reports

Volume: 6, P: 1-10
Chromosomal-level assembly of Tokudaia osimensis, Tokudaia tokunoshimensis, and Tokudaia muenninki genomes

Miki Okuno
Yuta Mochimaru
Takehiko Itoh
ResearchOpen Access21 Dec 2023
Scientific Data

Volume: 10, P: 1-10
Daple deficiency causes hearing loss in adult mice by inducing defects in cochlear stereocilia and apical microtubules

Yoshiyuki Ozono
Atsushi Tamura
Sachiko Tsukita
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-12
Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury

Koji Tamai
Hidetomi Terai
Satoshi Kato
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-9

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