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Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Scaling up of memristive passive crossbar circuits is the key challenge for applications in neuromorphic computing. Choi et al. demonstrate a wafer-scale fabrication of memristive passive crossbar circuits using a co-design approach for memristors and crossbar structures, enabling a device yield of over 95%.

Here the authors characterize the evolutionarily conserved role of the Arp2/3 actin nucleation complex in double-strand break mobility in budding yeast. Arp2/3 has important roles in end resection and Mec1-mediated DNA damage checkpoint activation.

Ferromagnets are an integral part of spintronics because of their spin selectivity, but in combination with superconductors selectivity between different Cooper pairs is required. Here, the authors find evidence for this selectivity in a ferromagnet–superconductor–ferromagnet spin valve.

Reconstruction of metal-organic frameworks occurs under reaction conditions, hindering mechanism understanding. Here, the authors identify the alkaline reconstructed β-Ni(OH)₂ with residual ligand that can catalyze the deprotonated anion of hydrogen peroxide at high current densities.

Mitochondrial dysfunction in dopaminergic neurons is a pathological hallmark of Parkinson’s disease. Here, the authors find a conserved mechanism by which a single transcription factor controls mitochondrial health in dopaminergic neurons during the aging process.

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

White adipose tissue (WAT) dysfunction leads to ageing-related metabolic disorders. Here, the authors show that the FMO3-TMAO axis in adipocytes induces senescence and inflammation in WAT microenvironment via NLRP3 inflammasome, leading to systemic glucose, lipid, and energy dysregulation in ageing

Analyses of whole-genome sequencing data from UK Biobank and All of Us identify rare variant burden signals associated with metabolic health, including effects of protein-truncating variants in IRS2 on type 2 diabetes and chronic kidney disease risk.

The authors estimate genomic vulnerability for closely related species of rainbowfish. They find that narrow endemic species that have hybridized with a warm-adapted generalist show reduced vulnerability to climate change and that hybridization may facilitate evolutionary rescue for such species.

A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Skin prick testing for allergy diagnosis is limited by variability due to differences in test setting and operator expertise. Here, the authors develop and validate an AI-assisted readout method for reading allergy skin test results, and find that integrating AI enhances standardization throughout the skin prick testing process.

BRCA2 has essential roles in suppressing genome instability at stalled replication forks, but how this is achieved remains unclear. Here, the authors apply Okazaki-fragment sequencing to predict sites of genomic instability caused by head-on transcription-replication conflicts upon BRCA2 loss.

Experiments performed in the CERN CLOUD chamber show that, under upper-tropospheric conditions, new atmospheric particle formation may be initiated by the reaction of hydroxyl radicals with isoprene emitted by rainforests.

The function of serotonin receptors and the neuroimmune relationship in psoriasis is not fully understood. Here, the authors find HTR2A antagonistic drugs worsened psoriasis outcomes in a study population, and that HTR2A modulation reduced psoriasis severity in imiquimod mouse models and that this involved HTR2A-expressing monocyte-derived Langerhans cells.

An analysis of the 3.45-Gyr-old volcanic sediments from the Kitty’s Gap Chert in Australia shows the presence of microfossils and highlights the difficulty of determining the biotic nature of structures in future extraterrestrial samples.

In this attempt at xenotransplantation of a lung from a genetically modified pig into a brain-dead recipient, although the grafted lung initially maintained viability and functionality, antibody-mediated rejection rapidly occurred, contributing to xenograft damage.

Fibrodysplasia ossificans progressiva is a severe disorder characterized by heterotopic ossification, and is caused by mutations in ACVR1. Here, the authors show that expression of mutant ACVR1 in fibro/adipogenic progenitors recapitulates disease progression, and that this can be halted by systemic inhibition of activin A in mice.

Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All isolates, their genomes and metadata are publicly available, facilitating research by others (www.hibc.rwth-aachen.de).

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.

The authors report that tensile strain applied to CsV₃Sb₅ strongly suppresses the charge-density-wave (CDW) gap, increases the mass of the fermions at the higher-order van Hove singularity (HO-VHS) and drives the energy of the HO-VHS towards the Fermi energy. Further, they suggest an important role of the HO-VHS in superconducting pairing.

The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.

Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.

Here the authors put forward a model in which the CtIP homolog Sae2 controls Mre11 endonuclease and 3’−5’ exonucleases via Rad50 by different mechanisms and reveals that the Mre11 endo-to-exonuclease switch is not required to process all blocked DNA ends

Landauer’s principle connects entropy and energy dissipation in non-equilibrium processes. An experiment now uses this principle to measure entropy production in a Bose gas to resolve contributions from correlations and dissipation.

Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Self-propelled motors operating at the micro- or nanoscale can be powered by catalytic reactions and show appealing potential in robotic applications. Brooks et al. describe how the motions of platinum spinners in hydrogen peroxide solutions can be rationally designed by controlling particle shape.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Enhancing the advanced oxidation processes used in potable reuse treatment trains represents an attractive target for reducing the energy intensity of the train. Switching the UV wavelength from 254 nm to 222 nm improves contaminant degradation by both direct photolysis and reaction with radicals, offering substantial efficiency gains.

Fasting diets are emerging as an approach to delay tumor progression and improve cancer therapies. Here, the authors show that the combination of fasting-mimicking diet with vitamin C decreases tumor development and increases chemotherapy efficacy in KRAS-mutant cancer.

Triggered therapeutics are of interest but currently suffer from limited penetration depth of light sources. Here, the authors report on the development of a system, called radioswitch, that uses ionising irradiation to switch an azobenzene modified drug to an active form for deep tissue triggered therapeutic application.