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The JAK2^V617F mutation leads to epigenetic rewiring in a cell-intrinsic and cell-type-specific manner, influencing inflammation states and differentiation trajectories in patients with myeloproliferative neoplasms.

CHA zeolites display high selectivity toward CO₂ adsorption, but the influence of the nature and concentration of their extra-framework cations on the formation of silanol sites, and the respective impact on CO₂ sorption, is poorly understood. Here, the authors use high-resolution solid-state magic-angle spinning ¹H NMR and Fourier-transform infrared spectroscopy to study the effects of post-synthetic exchange of extra-framework alkali-metal cations on silanol sites in nanosized CHA zeolites.

A generative AI approach is developed for predicting materials synthesis recipes—a complex challenge in materials science. Using this approach, the authors experimentally synthesized a material using AI-generated synthesis recipes.

The dynamic transformation of Cu ions during the selective catalytic reduction of NO_x on Cu zeolites is well documented, although the function of the zeolite framework has not been fully understood. Here the authors unravel the role of anionic Al sites in the zeolite framework in regulating the mobility and reactivity of Cu cations during catalysis.

The authors report that an AS03-adjuvanted chimeric hemagglutinin-based influenza vaccine induces persistent stalk-specific serum antibody and bone marrow plasma cell responses in nonhuman primates, offering promise for broader and durable flu protection.

Using slitless spectroscopy, JWST/NIRCam has simultaneously mapped three ice species across a dense cloud along 44 lines of sight. This cospatial mapping enables the local cloud chemistry to be probed with a spatial resolution of hundreds of astronomical units, representing a step change in ice mapping.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

In atrial fibrillation patients, circulating biomarkers reflecting inflammation, myocardial injury, and coagulation improve prediction of stroke, heart failure, and bleeding, outperforming clinical scores and enhance risk stratification.”.

A signal amplification circuit based on recycling nucleic acid inputs with RNA polymerase off-target transcription improves the sensitivity of transcription factor-based cell-free biosensors, achieving 10-fold decreases in limits of detection.

The Chamaeleon I dense cloud was observed with JWST as part of the Early Release Science programme ‘IceAge’. Here the authors present the detection of dangling OH features at ~2.7 μm, providing a tracer of icy grain morphology.

Cross-species studies show that loss of the synaptic adhesion molecules beat-Ia/CADM2 causes excessive sleepiness by disrupting development of wake-promoting NPF/NPY brain circuits. Targeting NPY signaling may offer treatment for human hypersomnia.

Vaccine-derived poliovirus type 2 currently spreads similarly to historical poliovirus—unidirectionally across neighbouring countries at a median velocity of 2.3 km per day. International borders are associated with slower velocity when immunity is high.

A distinct class of broadly neutralizing antibodies to the influenza virus target a membrane-proximal anchor epitope of the haemagglutinin stalk domain.

Divalent cation–exchanged zeolites enable complete ambient NO₂ removal with zero NO emission, overcoming a long-standing challenge in air purification and establishing a scalable pathway for zero-emission NO_x filtration.

Oral anticoagulants are the cornerstone of stroke risk prevention in patients with atrial fibrillation, regardless of whether sinus rhythm is restored. Evidence from two new randomized trials questions the need for long-term treatment with oral anticoagulants after successful ablation of atrial fibrillation and promises to change clinical practice.

New influenza virus vaccines tested in humans elicit broadly cross-reactive antibodies that bind the stalk of the viral hemagglutinin protein and may serve as templates to design a universal influenza vaccine.

An individual star at z = 1.49 is gravitationally lensed and highly magnified by a foreground galaxy cluster. Fluctuations in the star’s emission provide insight on the mass function of intracluster stars, compact objects and the presence of dark-matter subhaloes.

Small-pore zeolites that engender high selectivity for light olefins in the conversion of methanol to olefins deactivate rapidly due to the accumulation of unreactive carbonaceous deposits. Now, experiments show that high-pressure hydrogen added to the methanol feed can substantially enhance catalyst lifetime without compromising selectivity.

The mechanisms of thromboembolism in patients with atrial fibrillation are complex and not well understood, and existing stroke risk scores are limited in their predictive capacity. In this Review, Calenda et al. discuss stroke risk assessment in atrial fibrillation and explain how the atrial myopathy concept might help to refine stroke risk prediction.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Structurally convergent antibodies targeting the conserved influenza HA anchor epitope have provided a template for next-generation vaccine development. The authors identified four anchor antibodies encoded by diverse germline genes with broad neutralizing activity against influenza H1N1 viruses.

In a cluster-randomized trial conducted across 70 medical centers in six countries, a 16-week structured educational program for healthcare providers improved adherence to guidelines for rhythm control but not for stroke prevention in individuals with atrial fibrillation.

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Using 3D numerical models, this research shows how pre-existing rift basin structures influence the shape and growth of mountain belts, offering a way to link surface topography with deep Earth processes in regions like the Pyrenees and Caucasus.

A DNA walker driven by hybridization reactions can traverse the surface of a DNA-coated microparticle, taking more than 30 continuous steps.

Krisai et al. compare brain structure and cognitive function in elderly patients with and without atrial fibrillation using brain MRI and cognitive testing. They find that atrial fibrillation is associated with more brain lesions and lower cognitive function, but the cognitive impairment occurs primarily through direct effects of the arrhythmia rather than through brain damage.

CO oxidation catalysts face a tradeoff between high activity and stability due to oxidation-induced deactivation. By trapping Pt clusters at stepped CeO₂ pockets, this work circumvents the stability-activity dilemma.