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The JAK2^V617F mutation leads to epigenetic rewiring in a cell-intrinsic and cell-type-specific manner, influencing inflammation states and differentiation trajectories in patients with myeloproliferative neoplasms.

Using slitless spectroscopy, JWST/NIRCam has simultaneously mapped three ice species across a dense cloud along 44 lines of sight. This cospatial mapping enables the local cloud chemistry to be probed with a spatial resolution of hundreds of astronomical units, representing a step change in ice mapping.

In atrial fibrillation patients, circulating biomarkers reflecting inflammation, myocardial injury, and coagulation improve prediction of stroke, heart failure, and bleeding, outperforming clinical scores and enhance risk stratification.”.

CHA zeolites display high selectivity toward CO₂ adsorption, but the influence of the nature and concentration of their extra-framework cations on the formation of silanol sites, and the respective impact on CO₂ sorption, is poorly understood. Here, the authors use high-resolution solid-state magic-angle spinning ¹H NMR and Fourier-transform infrared spectroscopy to study the effects of post-synthetic exchange of extra-framework alkali-metal cations on silanol sites in nanosized CHA zeolites.

The dynamic transformation of Cu ions during the selective catalytic reduction of NO_x on Cu zeolites is well documented, although the function of the zeolite framework has not been fully understood. Here the authors unravel the role of anionic Al sites in the zeolite framework in regulating the mobility and reactivity of Cu cations during catalysis.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

A signal amplification circuit based on recycling nucleic acid inputs with RNA polymerase off-target transcription improves the sensitivity of transcription factor-based cell-free biosensors, achieving 10-fold decreases in limits of detection.

The Chamaeleon I dense cloud was observed with JWST as part of the Early Release Science programme ‘IceAge’. Here the authors present the detection of dangling OH features at ~2.7 μm, providing a tracer of icy grain morphology.

A distinct class of broadly neutralizing antibodies to the influenza virus target a membrane-proximal anchor epitope of the haemagglutinin stalk domain.

CO oxidation catalysts face a tradeoff between high activity and stability due to oxidation-induced deactivation. By trapping Pt clusters at stepped CeO₂ pockets, this work circumvents the stability-activity dilemma.

In a cluster-randomized trial conducted across 70 medical centers in six countries, a 16-week structured educational program for healthcare providers improved adherence to guidelines for rhythm control but not for stroke prevention in individuals with atrial fibrillation.

New influenza virus vaccines tested in humans elicit broadly cross-reactive antibodies that bind the stalk of the viral hemagglutinin protein and may serve as templates to design a universal influenza vaccine.

An individual star at z = 1.49 is gravitationally lensed and highly magnified by a foreground galaxy cluster. Fluctuations in the star’s emission provide insight on the mass function of intracluster stars, compact objects and the presence of dark-matter subhaloes.

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Small-pore zeolites that engender high selectivity for light olefins in the conversion of methanol to olefins deactivate rapidly due to the accumulation of unreactive carbonaceous deposits. Now, experiments show that high-pressure hydrogen added to the methanol feed can substantially enhance catalyst lifetime without compromising selectivity.

Structurally convergent antibodies targeting the conserved influenza HA anchor epitope have provided a template for next-generation vaccine development. The authors identified four anchor antibodies encoded by diverse germline genes with broad neutralizing activity against influenza H1N1 viruses.

The mechanisms of thromboembolism in patients with atrial fibrillation are complex and not well understood, and existing stroke risk scores are limited in their predictive capacity. In this Review, Calenda et al. discuss stroke risk assessment in atrial fibrillation and explain how the atrial myopathy concept might help to refine stroke risk prediction.

Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO₂ reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

As presented at the 2025 ASCO Annual Meeting: in a randomized platform phase II trial, high rates of pathologic complete response were seen for neoadjuvant durvalumab plus chemotherapy when combined with new agents, most notably a TROP2-targeting antibody–drug conjugate, in patients with resectable non-small-cell lung cancer.

A living passivation strategy enables dynamic self-healing of perovskite solar cells to ensure device performance and stability on exposure to heat or moisture.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

A DNA walker driven by hybridization reactions can traverse the surface of a DNA-coated microparticle, taking more than 30 continuous steps.

Antimicrobial resistance has evolved over decades due to widespread antimicrobial use, with resistance genes now circulating across humans, animals and the environment, creating complex cross-sector connectivity challenges. This Perspective advocates for genomics-based studies of AMR connectivity to enable coordinated global action and investment under the One Health framework.

The programmable nature of chemical reactions enables the creation of complex networks; however, it can be difficult to redesign the underlying reactions. Here, systematic and quantitative control over the diffusivity and reactivity of DNA molecules yields highly programmable chemical reaction networks that execute macroscale pattern transformation algorithms, such as edge detection.

Different membrane proteins dynamically polarize to organize signal transduction, but the underlying mechanism is unclear. Here, the authors show that a differential diffusion mediated partitioning process is sufficient to drive such spatiotemporal patterning of membrane-associated signaling proteins.

The doping efficiency of n-type molecular dopants in organic semiconductors is shown to depend on the energy difference between the electron affinity of the host and the ionization potential of the doped system.

This study reports an anatomical and functional screen of mushroom body–extrinsic neurons in Drosophila and finds that MB-V2 cholinergic efferent neurons are essential for retrieval of aversive short- and long-term memory, but not for memory formation or consolidation. During memory retrieval, MB-V2 neurons reinforce the olfactory pathway involved in innate odor avoidance.