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Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Wireless information security has garnered significant attention with the ever-increasingly widespread adoption of broadcast wireless communication systems. Here, authors design and experimentally verify a novel physical-layer secure communication scheme that relies on an information metasurface which is dynamically modulated by chaotic patterns

In this work, electron diffraction is used to measure the disorder parameter, Debye-Waller factors, and deformation electron density of FePd alloys. Chemical disorder raises atomic displacements but minimally alters deformation electron density.

The development of three-dimensional (3D) covalent organic frameworks (COFs) with novel topologies is of both fundamental and practical interest but the construction of highly crystalline 3D COF remains challenging. Here, the authors report highly crystalline 3D COFs with pto and mhq-z topologies by rationally selecting rectangular-planar and trigonal-planar building blocks with appropriate conformational strains.

Enzyme-catalysed 1,2-amino migration represents a viable biochemical process that is currently underutilized within the synthetic organic chemistry community. Building upon this biocatalytic mechanism, a biomimetic photoredox-catalysed 1,2-amino migration method has been developed. By integrating photoredox-catalysed conditions, this approach enables the modular synthesis of a diverse library of γ-substituted β-amino acids.

The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

The timely hepatitis B birth dose vaccination is recommended for all new-borns by the WHO, but coverage is inconsistent. Here, the authors model the impact of scaling-up coverage in 110 low and middle income countries and assess how it may be affected by delays for example caused by the COVID-19 pandemic.

Covalent organic frameworks form a porous skeleton with a precise pore size and geometry, but control of the pore surface is challenging. Here, a protocol is introduced for pore surface engineering of covalent organic frameworks, allowing the control of composition and density of organic groups in the pores.

Lenses with superior performance with respect to conventional uniform materials are desirable. The authors show a three-dimensional lens, made of multilayered metamaterials and based on approximate transformation optics, which works in different polarizations at broad viewing angles and with wide bandwidth.

Benzamides are widely found structural motifs, but their syntheses are largely derived from petrochemical-based feedstocks. Here the authors present the concept of “lignin to amides” with a one-pot, multi-step oxidation process utilizing molecular oxygen and a 3d-metal catalyst with highly dispersed and stable cobalt species (Co-SACs), supported on nitrogen-doped carbon in water as solvent.

Cationic polymers conventionally kill bacteria via physical membrane disruptions. Here, the authors report the development of carbon acid cationic polymers that show potent activity against multidrug-resistant strains in murine infection models and prevent bovine mastitis, and present evidence that these polymers translocate across bacterial membrane aided by N-heterocyclic carbene.

Though single-material organic solar cells are attractive for next-generation photovoltaic technologies, designing new materials with ideal properties remains a challenge. Here, the authors report the use of orientation-dependent molecular electrostatics to realise efficient homojunction devices.

Natural ecosystems efficiently sequester CO₂, but containing and controlling living systems remains challenging. Here, the authors engineer a photosynthetic living material for dual CO₂ sequestration via biomass accumulation and microbially-induced calcium carbonate precipitation.

Schizophrenia exhibits significant variability in brain structures, traditionally viewed as static due to heterogeneous subgroups. Here the authors use magnetic resonance imaging data from 1,792 individuals with schizophrenia to reveal that gray matter volume variability is greater in early stages and decreases over time, highlighting dynamic brain alterations with implications for understanding disease progression.

The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA1/2 mutation carriers exhibit significant molecular alterations in normal FTs before loss of heterozygosity (LOH) occurs, and suggest that tumorigenesis in BRCA1/2 carriers requires LOH or secondary genetic events rather than haploinsufficiency alone.

A real-time in situ magnetization reprogramming method for magnetic soft robots enables dynamic shape control, cooperative multi-tool manipulation and expanded actuation abilities.

The powdery mildew resistance of the MLIW170/PM26 locus, which originated from wild emmer wheat, is determined by a genetically linked atypical NLR gene pair, TdCNL1 and TdCNL5, with TdCNL1 encoding an atypical nucleotide-binding leucine-rich repeat protein integrating a potassium-dependent sodium-calcium exchanger domain.

Protein/protein interaction (PPI) interfaces have emerged as drug targets to develop medications with less side effects. Here, Dvorak et al. show that small molecule targeting of PPIs in the brain is an approach for psychiatric drug discovery.

This study reports Stomidazolone, a doubly-sulfonylated imidazolone that inhibits stomatal differentiation by binding to the ACT-Like domain of MUTE, disrupting its interaction with the bHLH partner SCREAM, which expands the chemical toolkit for manipulating bHLH-ACTL protein interactions, offering new avenues for controlling plant development.

A Fusarium graminearum effector is found to target wheat fumarylacetoacetate hydrolase for 26S proteasomal degradation. The hydrolase enhances resistance to Fusarium head blight by regulating defense genes and amino acid metabolism, offering a genetic target for wheat improvement.

Covalent organic frameworks (COFs) feature periodic layers and ordered pores that make them promising for applications in catalysis, but they typically suffer from poor stability. Now, adding methoxy groups to its pore walls has been shown to strengthen a COF's interlayer interactions, resulting in a stable, crystalline, porous material that can be further converted into chiral organocatalysts.

The oxygen reduction reaction (ORR) is limited by the scaling relationship in the conventional oxygen associative pathway. In this study, single p-block atoms and interstitial H are incorporated into Pd metallenes favoring the direct dissociation mechanism, leading to high alkaline ORR performance.

Preliminary results from a phase 2a trial involving 71 patients suggest that a new agent, discovered and designed with artificial intelligence assistance, is safe and effective for the treatment of idiopathic pulmonary fibrosis.

Enzymatic recycling of poly(ethylene terephthalate) (PET) offers a promising solution to plastic waste. This Review explores recent advances in engineering PET-degrading enzymes, highlighting trends in rational design and directed evolution toward more effective and economical recycling processes.

Metadevices that are based on quasi-one-dimensional surface plasmon polariton structures can offer optical and radiofrequency transparency, and can be used to create a wireless communication scheme for image transfer.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

Bleaching threatens corals worldwide as the oceans warm from climate change. Here the authors provide insight into intergenerational acclimatization potential by identifying metabolomic signatures of coral resistance to bleaching at all stages of development, including in the new generation.

The tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors.

Adenoids and tonsils in children can become hypertrophic because of multiple infections. Here the authors use single cell transcriptomics to assess the immune cell composition of these hypertrophic organs and find B, T and NK cells and exhausted memory CD4 T cells indicating immune changes in these organs associated with respiratory infection.

Highly pathogenic avian influenza is an increasing global concern but its distribution in remote regions is not known. Here, the authors conduct an environmental influenza surveillance study in remote, uninhabited regions of the Global South by sampling fresh bird guano.

The Ton and Tol systems are bacterial energy-transducing complexes that use the proton motive force at the inner membrane to exert force on outer membrane proteins. Here the authors present the high-resolution cryoEM structures of the inner membrane engine part of these two complexes.

Exploiting as many degrees of freedom of the electron as possible will make future electronic devices more versatile. Here, the authors show that coupling of spin, layer pseudospin and valley degrees of freedom in transition metal dichalcogenide bilayers makes them a promising platform for this purpose.

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

Grignard reagents have widespread utility in organic chemistry, but their preparation is limited by several drawbacks, such as the use of dry organic solvents and long reaction times. Here, the authors report a general mechanochemical synthesis of Grignard reagents in paste form in air, using a ball milling technique.

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) that use phosphorylation in their reaction mechanisms.

Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcus anaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.

Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

Current collectors are essential components in lithium-ion batteries, but are typically made of metal foils that do not contribute to the battery capacity. Now, a fire-extinguishing lightweight polymer-based current collector is developed that enhances both the energy density and safety of the battery.