Nature Search

Interleukin-15 protects from lethal apoptosis in vivo

Silvia Bulfone-Paus
Daniela Ungureanu
Ulrich Kunzendorf
Research01 Oct 1997
Nature Medicine

Volume: 3, P: 1124-1128
Catalytic asymmetric cationic shifts of aliphatic hydrocarbons

We describe an imidodiphosphorimidate-catalysed asymmetric Wagner–Meerwein shift of aliphatic alkenyl cycloalkanes to cycloalkenes with excellent regio- and enantioselectivity.

Vijay N. Wakchaure
William DeSnoo
Benjamin List
ResearchOpen Access10 Jan 2024
Nature

Volume: 625, P: 287-292
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
A multi-substrate screening approach for the identification of a broadly applicable Diels–Alder catalyst

Investigation of a reaction scope usually starts with the optimization for a model substrate. Here, the authors apply a time-efficient multi-substrate screening approach to identify a general organocatalyst for the Diels–Alder reaction of cyclopentadiene with α,β-unsaturated aldehydes.

Hyejin Kim
Gabriela Gerosa
Benjamin List
ResearchOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-6
Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

Secretory IgA (SIgA) shapes the gut microbial composition. Pabst and colleagues show that the IgA-secreting plasma cell repertoire, once established, is remarkably resilient to changes in microbial populations that occur upon infection or antibiotic treatment.

Cornelia Lindner
Irene Thomsen
Oliver Pabst
Research29 Jun 2015
Nature Immunology

Volume: 16, P: 880-888
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Thermal control of sequential on-surface transformation of a hydrocarbon molecule on a copper surface

On-surface chemical reactions provide an attractive route for making tailored nanostructures. Here the authors present a thermally-controlled sequential on-surface transformation of a hydrocarbon molecule, characterized via high-resolution atomic force microscopy and density functional theory calculations.

Shigeki Kawai
Ville Haapasilta
Ernst Meyer
ResearchOpen Access13 Sept 2016
Nature Communications

Volume: 7, P: 1-7
Multistable inflatable origami structures at the metre scale

Origami-inspired multistable structures that can be inflated from flat to three dimensions have been designed; a library of foldable shapes is created and then combined to build metre-scale functional structures.

David Melancon
Benjamin Gorissen
Katia Bertoldi
Research21 Apr 2021
Nature

Volume: 592, P: 545-550
Comprehensive genomic profiles of small cell lung cancer

Genomic sequencing of 110 human small cell lung cancers identifies genomic signatures including nearly ubiquitous bi-allelic inactivation of TP53 and RB1, a role for NOTCH family genes, and somatic rearrangements that create an oncogenic version of TP73.

Julie George
Jing Shan Lim
Roman K. Thomas
Research13 Jul 2015
Nature

Volume: 524, P: 47-53
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

P: 1-11
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Mutations in the HECT domain of NEDD4L lead to AKT–mTOR pathway deregulation and cause periventricular nodular heterotopia

Jamel Chelly and colleagues identify mutations in the E3 ubiquitin ligase gene NEDD4L that cause a syndrome of periventricular nodular heterotopia associated with neurodevelopmental disorders, cleft palate and toe syndactyly. The authors show that the mutations affect the mTORC1 and AKT pathways and cause defects in mouse brain development.

Loïc Broix
Hélène Jagline
Jamel Chelly
Research03 Oct 2016
Nature Genetics

Volume: 48, P: 1349-1358
Molecular consequences of SARS-CoV-2 liver tropism

Wanner et al. demonstrate SARS-CoV-2 liver tropism and identify transcriptional and proteomic profiles of SARS-CoV-2 liver samples that show similarities to previously characterized hepatotropic viruses.

Nicola Wanner
Geoffroy Andrieux
Tobias B. Huber
ResearchOpen Access28 Mar 2022
Nature Metabolism

Volume: 4, P: 310-319
Pivoting of microtubules around the spindle pole accelerates kinetochore capture

To segregate chromosomes, spindle microtubules must attach to chromosomes through kinetochores, in a process involving several types of microtubule behaviour. Tolic-Norrelykke and colleagues find that fission yeast microtubules rapidly rotate around the spindle poles, and mathematical modelling confirms that this random microtubule movement facilitates kinetochore capture.

Iana Kalinina
Amitabha Nandi
Iva M. Tolić-Nørrelykke
Research09 Dec 2012
Nature Cell Biology

Volume: 15, P: 82-87
A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells

Benjamin Lindner
Eva Martin
Michael Schuler
ResearchOpen Access21 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes

Benjamin Kloth
Giulia Mearini
Marc N. Hirt
ResearchOpen Access17 May 2022
Scientific Reports

Volume: 12, P: 1-12
Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)

Tatjana Meyer
Nikolaus Jahn
Jan Krönke
ResearchOpen Access01 Oct 2019
Leukemia

Volume: 34, P: 404-415
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

S H Witt
F Streit
M Rietschel
ResearchOpen Access20 Jun 2017
Translational Psychiatry

Volume: 7, P: e1155
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298

Search

Interleukin-15 protects from lethal apoptosis in vivo

Catalytic asymmetric cationic shifts of aliphatic hydrocarbons

Genomics yields biological and phenotypic insights into bipolar disorder

A multi-substrate screening approach for the identification of a broadly applicable Diels–Alder catalyst

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Thermal control of sequential on-surface transformation of a hydrocarbon molecule on a copper surface

Multistable inflatable origami structures at the metre scale

Comprehensive genomic profiles of small cell lung cancer

Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Genome-wide association study identifies 30 loci associated with bipolar disorder

Mutations in the HECT domain of NEDD4L lead to AKT–mTOR pathway deregulation and cause periventricular nodular heterotopia

Molecular consequences of SARS-CoV-2 liver tropism

Pivoting of microtubules around the spindle pole accelerates kinetochore capture

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells

Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes

Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

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