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Using extended-gate capacitive coupling and diode connection, stretchable biosensors with a built-in differential circuit design can be created that can offer low signal distortion under bias stress instability, uniaxial strain, compression and temperature variations.

A deep-learning framework that predicts genome-wide somatic copy number aberrations across diverse cancer types using only RNA-seq data.

Developing photocatalysts from earth-abundant materials is crucial for sustainable solar hydrogen production, yet challenges in efficiency and stability persist. Here, the authors report that the topological semimetal cobalt triarsenide functions as an active and durable platform for this reaction.

Diethyl ethylphosphonate (DEEP) is a promising candidate for developing non- flammable electrolytes for wide-temperature application in Li-ion batteries, but low compatibility with graphite electrodes and slow ionic transport hinder its implementation. Here, the authors show that incorporating diethylene glycol dimethyl ether into a DEEP-based electrolyte enhances ion transport and improves low-temperature performance in graphite-based cells.

Expanding editing scope while reducing byproducts is now possible for prime editing. Here, authors develop reverse prime editing (rPE), a SpCas9-based tool enabling editing in reverse window with high fidelity and demonstrate its use in inserting therapeutic variants.

Here, Ying Li et al. present the results of a randomized controlled feeding trial in prediabetes participants, finding that advancing timing of unsaturated fat (USFA) intake improves insulin sensitivity through the gut microbiome and bile acid metabolism, regardless of USFA type.

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

The authors achieve precipitate alignment in piezoceramic by applying a uniaxial stress during aging process, resulting in electrical anisotropy. The optimized material has succinct advantages for high-power piezoelectric applications.

Functional oxides with coexisting states of comparable energy typically exhibit extraordinary responses to external stimuli. Here, the authors demonstrate that coexisting phase structures provide large electric field-triggered volume change.

Global riverine carbon export to the ocean may exceed previous estimates, underscoring the important role of riverine carbon to the carbon budget, according to a multi-model ensemble assessment constrained by a global dataset.

Prime editing enables precise and efficient genome editing, but its efficacy is hindered by pegRNA’s 3’ extension. Here the authors develop a mismatched pegRNA (mpegRNA) strategy to reduce complementarity and secondary structure formation and can increase prime editing efficiency and reduce indels.

A prophylactic cancer vaccine consisting of commercial adjuvants wrapped by membranes from pluripotent stem cells inhibited tumour progression in mice, owing to shared antigens between tumour membranes and the pluripotent stem cell membranes.

Renewable-powered CO₂ electroreduction offers a sustainable path to mitigate climate and energy challenges. Here, the authors report a non-isothermal strategy to enhance electrochemical performance and leverage the Soret effect to prevent salt precipitation for long term stability.

Early life factors like breastfeeding and maternal smoking may influence oesophageal cancer risk in adults. Here, the authors analyse data from the UK biobank and show that breastfeeding is associated with reduced incidence and mortality of oesophageal cancer and reduced adverse effects of smoking in offspring.

Zhong et al. find that SERRATE (SE) regulates the m⁶A methyltransferase complex (MTC) to control m⁶A deposition, and show cross-regulation between the MTC and the SE-mediated microprocessor governs miRNA production in Arabidopsis.

RNA secondary structure is a new regulatory layer of transcript fates. Here, Li et al. find that plant RNA helicase Brr2a, acting beyond its canonical role in spliceosome, can optimize secondary structure of pri-miRNAs to promote miRNA production.

An electronic skin that is capable of long-term monitoring of vital signs and molecular biomarkers in sweat can—with the help of machine learning—be used to classify stress responses with high accuracy and predict state anxiety levels with high reliability.

Analysis of 43,191 genomes obtained from publicly available marine bacterial and archaeal metagenome data provides insights into marine bacterial evolution, CRISPR–Cas defence and antibiotic resistance genes, and demonstrates the potential of marine metagenomes for biotechnological applications.

Base editors lacking a deaminase improve thymine and cytosine conversion.

Confined biofilms can shape themselves and their boundary to modify their internal organisation. This mechanism could inform the development of active materials that control their own geometry.

Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.

The limited solubility and slow diffusion of CO₂ in aqueous electrolytes represent a challenge for electrochemical CO₂ conversion in aqueous systems, imposing significant mass transfer barriers, particularly at high current densities. Here, the authors introduce a nanobubble-infused electrolyte strategy that leverages the unique properties of nanobubbles, including localized CO₂ enrichment, enhanced diffusion, and micro-convection to achieve a 10-fold increase in the volumetric mass transfer coefficient and a 42.3% improvement in the limiting current density.

Here, the authors design a “beyond aqueous” colloidal electrolyte with ultralow salt concentration and inherent low freezing point and investigate its colloidal behaviors and underlying mechanistic principles to stabilize cryogenic Zn metal battery.

Current wearable and implantable biosensors still face challenges to improve sensitivity, stability and scalability. Here the authors report inkjet-printable, mass-producible core–shell nanoparticle-based biosensors to monitor a broad range of biomarkers.

ATP acts as a co-substrate in enzyme catalysed reactions, but can also specifically bind metal ions. Here, the authors show that ATP interacts with copper ions and forms a Cu(II)-ATP complex that efficiently catalyses Diels-Alder reactions, and determine ATP residues that are essential for this activity.

Renewable-energy-powered electrolysis of seawater provides a sustainable means of mass production of hydrogen, a critical fuel for tomorrow’s energy mix. Here the layered double hydroxide (LDH) electrocatalyst design enables ultrastable seawater splitting at industry-compatible current densities.

A large number of cell disease models with pathogenic SNVs are needed. Here the authors report an automated high-throughput platform to perform the genome editing process from gRNA design to the analysis of the editing results; they characterise in situ base editing outcomes.

Base editing technology has great potential in treating pathogenic single-nucleotide variations. Using a dual-AAV base editing system, Wu et al. restored visual functions in a mouse model of retinitis pigmentosa.

Limited work has been done on concurrent C-to-G and A-to-G base editing. Here the authors test how a number of chromatin-associated factors affect base editing and show that HMGN1 enhanced the efficiency; by fusing HMGN1 to GBE and ABE they develop a CRISPR-based dual-function A-to-G and C-to-G base editor (GGBE).

Achieving long-term stable photoelectrochemical water decomposition in highly corrosive seawater remains a challenge. Here, the authors report a strategy for enhancing metal-oxygen interaction to achieve high stability of metastable β-Fe₂O₃ photoelectrochemical seawater splitting.

A reagentless, wireless, wearable aptamer nanobiosensor interfaced with a gold nanoparticle-MXene-based electrode enables the selective, automatic and non-invasive analysis of the female hormone oestradiol in sweat during menstrual cycles with subpicomolar sensitivity.

Parallel degradome sequencing and DMS-MaPseq pinpoint the first cleavage sites on bona fide pri-miRNAs, decode their in vivo structure and provide better interpretation of the cleavage modes and impact of DCL1 cofactors in the process in Arabidopsis.

Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different gene loci.

A wearable electrochemical biosensor can continuously detect, in sweat during physical exercise and at rest, trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.

Geminiviruses hijack the host DNA repairing proteins for their amplification. The authors report that Arabidopsis loses H3.1K27me1, a protector of genome stability, but gains resistance to geminivirus infection via retaining key factors like RAD51.

A wearable electrochemical patch for the real-time monitoring of the biomarker C-reactive protein in sweat detects elevated concentrations of the protein in patients with acute or chronic inflammation.

The assembly of active and self-propelled particles is an emerging strategy to create dynamic materials otherwise impossible. Here, the authors show the assembly of active colloidal molecules with a wide spectrum of new structures and dynamics, conferred to them by highly selective and directional interactions.

Bacterial biofilms exhibit complex spatiotemporal pattern formation. Here the authors report a collective cell reorientation cascade in growing Vibrio cholerae biofilms that leads to a differentially ordered, spatiotemporally coupled core-rim structure.

New base editors change C to A in bacteria and C to G in mammalian cells.